Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity
Bonjoch, Anna (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Echeverría, Patricia (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Pérez-Álvarez, Núria (Universitat Politècnica de Catalunya)
Puig, Jordi (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Estany Quera, Carla (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Medicina)
Negredo Puigmal, Eugènia (Universitat de Vic - Universitat Central de Catalunya)

Date:	2016
Abstract:	Background. Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce. Methods. This is an observational prospective study including all patients that presented at our HIV Unit who interrupted TDF owing to nephrotoxicity. We assessed the evolution of renal parameters after discontinuation of this drug. Results. We included 59 patients, who were followed up for 72 weeks. Most were male (41, 69. 5%), median (IQR) age was 53 (44; 58) years, and median time receiving TDF-containing regimens was 55. 4 (28; 87. 7) months. Most patients were receiving PI-based treatments (67%). At the final visit, most of the subjects showed complete recovery (35, 59. 3%) or improvement (13 subjects, 22%). Significant improvements were observed in creatinine levels (from 84. 9 [73. 8; 97. 5] to 78 [69. 6; 91] μ mol/L, p = 0. 013), estimated glomerular filtration rate (eGFR, CKD EPI equation, from 87. 7 [67; 99] to 89. 9 [73. 6; 99. 3] mL/min/1. 73 m 2, p = 0. 017), and number of patients with eGFR <60 mL/min/1. 73 m 2 (from 9 [15. 3%] to 1 [1. 7%], p = 0. 031). A trend toward significance was observed in abnormal urine proteinuria/creatinine ratio (from 22 [37%] to 8 [13. 6%], p = 0. 057). Conclusions. Our results corroborate the high frequency of complete or partial renal recovery in patients receiving TDF-containing regimens who discontinued therapy owing to nephrotoxicity.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	BioMed Research International, Vol. 2016 (december 2016) , ISSN 2314-6141

DOI: 10.1155/2016/4380845
PMID: 28078289

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
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