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| Pàgina inicial > Articles > Articles publicats > Plasma Chemokines in Patients with Alcohol Use Disorders : |
(Universidad Complutense de Madrid. Facultad de Psicología) (Instituto de Investigación Biomédica de Málaga) (Universidad Autónoma de Madrid) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Universidad Autónoma de Madrid)| Data: | 2017 |
| Resum: | Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C-C motif (CC), C-X-C motif (CXC), and C-X-C motif (CXC) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p < 0. 001) and CXCL1/fractalkine (p < 0. 05) were lower in AUD patients compared to controls, whereas CCL11/eotaxin-1 concentrations were strongly decreased in female AUD patients (p < 0. 001). In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0. 456, p < 0. 001) and gamma-glutamyltransferase (r = +0. 647, p < 0. 001). Focusing on comorbid psychiatric disorders, we distinguish between patients with additional mental disorders (N = 61) and other substance use disorders (N = 38). Only CCL11 concentrations were found to be altered in AUD patients diagnosed with mental disorders (p < 0. 01) with a strong main effect of sex. Thus, patients with mood disorders (N = 42) and/or anxiety (N = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women. The alcohol-induced alterations in circulating chemokines were also explored in preclinical models of alcohol use with male Wistar rats. Rats exposed to repeated ethanol (3 g/kg, gavage) had lower CXCL12 (p < 0. 01) concentrations and higher CCL11 concentrations (p < 0. 001) relative to vehicle-treated rats. Additionally, the increased CCL11 concentrations in rats exposed to ethanol were enhanced by the prior exposure to restraint stress (p < 0. 01). Concordantly, acute ethanol exposure induced changes in CXCL12, CXCL1, and CCL11 in the same direction to repeated exposure. These results clearly indicate a contribution of specific chemokines to the phenotype of AUD and a strong effect of sex, revealing a link of CCL11 to alcohol and anxiety/stress. |
| Ajuts: | Ministerio de Economía y Competitividad PI13/02261 Ministerio de Economía y Competitividad PI16/01953 Ministerio de Economía y Competitividad CP14/00173 Ministerio de Economía y Competitividad CP14/00212 Ministerio de Economía y Competitividad CD12/00455 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Chemokine ; Alcohol use disorder ; Psychiatric comorbidity ; Outpatient setting ; PRISM ; Eotaxin ; Sex |
| Publicat a: | Frontiers in psychiatry, Vol. 7 (january 2017) , ISSN 1664-0640 |
