Field evaluation of the efficacy of Mycobacterium bovis BCG vaccine against tuberculosis in goats
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Arrieta-Villegas, Claudia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Grasa, Miriam (Associació de Ramaders de Cabrum de Catalunya)
Mercader, Irene (Generalitat de Catalunya. Departament d'Agricultura, Ramaderia, Pesca i Alimentació (DARP))
Domingo, Mariano (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Pérez de Val, Bernat (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)

Data:	2017
Resum:	Control of animal tuberculosis (TB) through vaccination has emerged as a long-term strategy to complement test and slaughter control strategy. A pilot trial under field conditions was conducted in a goat herd with high TB prevalence to assess the efficacy of the Mycobacterium bovis BCG vaccine. Twenty-three goat kids vaccinated with BCG and other 22 unvaccinated control kids were euthanized at 18 months post-vaccination. Gross pathological and histopathological examination of target tissues was performed for detection of tuberculous lesions and assessment of vaccine efficacy. Mycobacterial culture and DNA detection were used to confirm Mycobacterium caprae infection. Vaccination significantly reduced the number of animals with TB lesions compared to unvaccinated controls (35% and 77%, respectively; P < 0. 01). This reduction was even higher if only extra-pulmonary infection was considered (17% and 68%, respectively; P < 0. 001). This trial demonstrates that BCG vaccination of goats can significantly reduce the TB lesion rates in high disease exposure conditions, indicating that vaccination could contribute to the control of TB in domestic goats.
Ajuts:	Ministerio de Economía y Competitividad AGL2012-36171 Generalitat de Catalunya AGL2012-36171
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	BCG ; Efficacy ; Field study ; Goats ; Tuberculosis ; Vaccine
Publicat a:	BMC veterinary research, Vol. 13 (august 2017) , ISSN 1746-6148

DOI: 10.1186/s12917-017-1182-5
PMID: 28818102

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