Altered cross-talk between the hypothalamus and non-homeostatic regions linked to obesity and difficulty to lose weight
Contreras Rodríguez, Oren (Institut d'Investigació Biomèdica de Bellvitge)
Vilar-López, Raquel (Universidad de Granada. Mind, Brain and Behavior Research Center)
Andrews, Zane B. (Monash Biomedicine Discovery Institute. Metabolic Disease and Obesity Program)
Navas, Juan F.. (University of Granada. Department of Experimental Psychology)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Verdejo-García, Antonio (Monash University. School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences)

Data:	2017
Resum:	Interactions between the hypothalamus and non-homeostatic regions may contribute to explain the difficulty to lose weight in obesity, an assumption never tested in human longitudinal studies. We investigated whether the functional connectivity between the medial and lateral hypothalamus (MH and LH) and corticostriatal regions differs between individuals with excess weight (n = 42) and normal weight (n = 39) using a seed-based resting-state approach. In addition, we examined the longitudinal association between functional connectivity and weight loss in a 3-month follow-up diet. Results showed that participants with excess weight had increased connectivity between the MH and the striatum and subgenual anterior cingulate cortex, and decreased connectivity with the middle frontal gyrus, and the bed nucleus of the stria terminalis (BNST), as well as a decreased connectivity between the LH and the cerebellum. Decreased connectivity between the MH and the posterior part of the BNST, and between the LH and the cerebellar cortex, predicted a greater percentage of weight loss. Functional connectivity measures explained 36% of the 3-month weight change among individuals with excess weight. We conclude that altered functional connectivity between homeostatic-hypothalamic regions and non-homeostatic corticostriatal and cerebellar regions is linked to obesity and difficulty to lose weight.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Scientific reports, Vol. 7 (august 2017) , ISSN 2045-2322

DOI: 10.1038/s41598-017-09874-y
PMID: 28855582

9 p, 1.3 MB

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