New diagnoses of human immunodeficiency virus infection in the Spanish pediatric HIV Cohort (CoRISpe) from 2004 to 2013
Jiménez de Ory, Santiago (Hospital Universitari Vall d'Hebron)
González-Tomé, María Isabel (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Fortuny Guasch, Claudia (Hospital Sant Joan de Déu (Manresa))
Mellado, Maria Jose (Hospital Universitario infantil La Paz (Madrid))
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bustillo, Matilde (Hospital Universitario Miguel Servet (Saragossa))
Ramos-Amador, José-Tomás (Hospital Clínico San Carlos (Madrid))
Muñoz-Fernández, Maria Angeles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Navarro, Maria Luisa (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Universitat Autònoma de Barcelona

Data:	2017
Resum:	Vertical human immunodeficiency virus (HIV) infection has decreased in industrialized countries in recent decades, but there are no studies on the mechanisms of HIV transmission among infected children in Spain. Our aim was to study the characteristics and trends of diagnoses of vertically HIV-infected children in Spain from 2004 to 2013. Vertically HIV-infected children were selected if they were diagnosed from 2004 to 2013, were aged 0 to 18 years old, and were included in the Cohort of the Spanish Pediatric HIV Network (CoRISpe). Demographic, clinical, immunological, and virological data at diagnosis were obtained. The rate of diagnoses of vertically HIV-infected children was calculated as the number of cases per 100,000 inhabitants. Obstetric data of mothers of Spanish children and prophylaxis at childbirth and postpartum were obtained. A total of 218 HIV-infected children were included in the study. Of this sample, 182 children (83. 5%) were perinatally HIV infected, and 125 out of those 182 children (68. 7%) were born in Spain. The vertically HIV-infected Spanish children were diagnosed earlier and were in better clinical and immunological condition at diagnosis than were foreign children. The rate of vertically HIV-infected children declined from 0. 09 in 2004 to 0. 03 in 2013 due to the decrease in the rate of children born in Spain (0. 08 in 2004 vs 0. 01 in 2013). A total of 60 out of 107 mothers (56. 1%) of Spanish children were diagnosed at or after childbirth. However, this number declined between 2004 and 2013. The rate of new HIV diagnoses of vertically HIV-infected children decreased significantly between 2004 and 2013 from 0. 09 to 0. 03 per 100,000 inhabitants.
Ajuts:	Ministerio de Economía y Competitividad RD12/0017/0037 Ministerio de Economía y Competitividad RD16/0025/0019
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adolescents ; Children ; HIV ; New diagnoses ; Vertical transmission
Publicat a:	Medicine, Vol. 96 (september 2017) , ISSN 1536-5964

DOI: 10.1097/MD.0000000000007858
PMID: 28953612

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