Evolution of acute hepatitis C virus infection in a large European city : Trends and new patterns
Garriga, César (Centro Nacional de Epidemiología (Espanya))
Manzanares-Laya, Sandra (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
García de Olalla, Patricia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Gorrindo, Pilar (Agència de Salut Pública de Barcelona)
Lens, Sabela (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Solà, Ricard (Hospital del Mar (Barcelona, Catalunya))
Martínez-Rebollar, María (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Laguno Centeno, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Torras, Xavier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Gurguí, Mercè (Institut d'Investigació Biomèdica Sant Pau)
Barberà, Maria Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Masdeu, Eva (Agència de Salut Pública de Barcelona)
Simón Vivan, Pere (Agència de Salut Pública de Barcelona)
Ros, Miriam (Agència de Salut Pública de Barcelona)
De Andrés, Anna (Agència de Salut Pública de Barcelona)
Caylà, Joan A.. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004-2005, 2006-2011 and 2012-2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35-54 had higher IR. IRR for men was 2. 9 times greater than in women (95% confidence intervals (CI): 1. 8 ‒ 4. 7). Factors related to the period 2012-2015 (versus 2006-2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13. 0; 95% CI: 2. 3 ‒ 72. 1), b) higher educated versus lower (RRR: 5. 4; 95% CI: 1. 6 ‒ 18. 7), and c) HIV co-infected versus not HIV-infected (RRR: 53. 1; 95% CI: 5. 7 ‒ 492. 6). This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual.
Grants:	Instituto de Salud Carlos III 12/PEAC-06
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 12 (november 2017) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0187893
PMID: 29135988

16 p, 2.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles