The Role of Morbid Obesity in the Promotion of Metabolic Disruptions and Non-Alcoholic Steatohepatitis by Helicobacter Pylori
Lecube, Albert (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Valladares, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
López-Cano, Carolina (Hospital Arnau de Vilanova (Lleida, Catalunya))
Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fort, José Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Reñé, Josep Maria (Hospital Arnau de Vilanova (Lleida, Catalunya))
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya))
de Torres, Inés (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bueno, Marta (Hospital Arnau de Vilanova (Lleida, Catalunya))
Pallarés, Judit (Hospital Arnau de Vilanova (Lleida, Catalunya))
Baena-Fustegueras, Juan Antonio (Hospital Arnau de Vilanova (Lleida, Catalunya))
Universitat Autònoma de Barcelona

Data:	2016
Resum:	Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant and no studies exist in morbidly obese patients, in which both insulin resistance and inflammation coexist. Cross-sectional study to evaluate the relationship between HP infection and alterations in carbohydrate metabolism, lipid profile, inflammation markers, and liver disease in patients awaiting for bariatric surgery. HP infection was histologically assessed in gastric antrum biopsy from 416 subjects. Liver biopsy was also available in 93 subjects. Both impaired fasting glucose and T2D were similar when comparing subjects with and without HP infection (24. 2% vs. 22%, p = 0. 290 and 29. 4% vs. 29. 1%, p = 0. 916, respectively), with no differences between groups in the HOMA-IR, lipid profile neither inflammatory parameters. However, HP infection was higher among subjects with a BMI ≥ 40. 0 kg/m 2 in comparison with lower degrees of obesity (71. 7% vs. 60. 0%, p = 0. 041). In addition, subjects without HP infection showed higher degrees of steatosis (44. 1±26. 4% vs. 32. 0±20. 7%, p = 0. 038), as well as a lower prevalence of non-alcoholic steatohepatitis (9. 3% vs. 30. 7%, p = 0. 023). In patients with morbid obesity, HP infection does not seem to be associated with abnormal carbohydrate metabolism. In addition, less advanced degrees of non-alcoholic fatty disease were observed. We suggest that low-grade inflammation that accompanies obesity mitigates the diabetogenic effect of HP, so the presence of obesity should be considered in studies that evaluate the HP metabolic effects.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 11 (november 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0166741
PMID: 27893763

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