Influence of the LILRA3 Deletion on Multiple Sclerosis Risk : Original Data and Meta-Analysis
Ortiz, Miguel A. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Núñez, Concepción (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Ordóñez, David (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana)
Alvarez-Cermeño, José C. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Martínez-Rodriguez, José E. (Institut Hospital del Mar d'Investigacions Mèdiques)
Sánchez, Antonio J. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Arroyo, Rafael (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Montalban, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina)
García-Merino, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Munteis, Elvira (Institut Hospital del Mar d'Investigacions Mèdiques)
Alcina, Antonio (Instituto de Parasitología y Biomedicina "López-Neyra")
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra")
Villar, Luisa M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)

Date:	2015
Abstract:	Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results. In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities. Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0. 25, OR (95% CI) = 1. 07 (0. 95-1. 19)], even after stratification by gender and the HLA-DRB1*15 : 01 risk allele.
Grants:	Instituto de Salud Carlos III PI12/00555 Ministerio de Economía y Competitividad PI13/01527 Ministerio de Economía y Competitividad PI13/01466 Ministerio de Economía y Competitividad PI13/00879 Ministerio de Economía y Competitividad RD12/0032/0006
Note:	Altres ajuts: Junta de Andalucía (JA)- Fondos Europeos de Desarrollo Regional (FEDER) (grant number CTS2704 to FM).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 10 (august 2015) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0134414
PMID: 26274821

10 p, 925.4 KB

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