Neurophysiological Evidence of Compensatory Brain Mechanisms in Early-Stage Multiple Sclerosis
López-Góngora, Mariana (Institut d'Investigació Biomèdica Sant Pau)
Escartín Siquier, Antonio E. (Institut d'Investigació Biomèdica Sant Pau)
Martínez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau)
Fernandez-Bobadilla, Ramon (Institut d'Investigació Biomèdica Sant Pau)
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Romero, Sergio (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Mañanas, Miquel Àngel (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Riba, Jordi (Centro de Investigación Biomédica en Red de Salud Mental)
Universitat Autònoma de Barcelona

Date:	2015
Abstract:	Multiple sclerosis (MS) is a chronic central nervous system disorder characterized by white matter inflammation, demyelination and neurodegeneration. Although cognitive dysfunction is a common manifestation, it may go unnoticed in recently-diagnosed patients. Prior studies suggest MS patients develop compensatory mechanisms potentially involving enhanced performance monitoring. Here we assessed the performance monitoring system in early-stage MS patients using the error-related negativity (ERN), an event-related brain potential (ERP) observed following behavioral errors. Twenty-seven early-stage MS patients and 31 controls were neuropsychologically assessed. Electroencephalography recordings were obtained while participants performed: a) a stop task and b) an auditory oddball task. Behavior and ERP measures were assessed. No differences in performance were found between groups in most neuropsychological tests or in behavior or ERP components in the auditory oddball task. However, the amplitude of the ERN associated with stop errors in the stop task was significantly higher in patients. ERN amplitude correlated positively with scores on the Expanded Disability Status Scale and the Multiple Sclerosis Severity Score, and negatively with the time since last relapse. Patients showed higher neuronal recruitment in tasks involving performance monitoring. Results suggest the development of compensatory brain mechanisms in early-stage MS and reflect the sensitivity of the ERN to detect these changes.
Grants:	Ministerio de Economía y Competitividad JR13/00014
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 10 (august 2015) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0136786
PMID: 26322632

15 p, 774.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles