Serum sCD163 Levels Are Associated with Type 2 Diabetes Mellitus and Are Influenced by Coffee and Wine Consumption : Results of the Di@bet.es Study
Rojo-Martínez, G (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Maymó-Masip, Elsa (Hospital Universitari Joan XXIII de Tarragona)
Rodríguez, M. Mar (Institut d'Investigació Biomèdica de Girona)
Solano, Esther (Hospital Universitari Joan XXIII de Tarragona)
Goday Arnó, Albert (Universitat Autònoma de Barcelona. Departament de Medicina)
Soriguer, Federico (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Valdés, Sergio (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Chaves, Felilpe Javier (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Delgado, Elias (Hospital Universitario Central de Asturias)
Colomo, Natalia (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Hernández, Pilar (Hospital Universitari Joan XXIII de Tarragona)
Vendrell, Joan (Hospital Universitari Joan XXIII de Tarragona)
Chacón, Matilde R. (Hospital Universitari Joan XXIII de Tarragona)

Data:	2014
Resum:	Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet. es study. This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet. es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes. sCD163 concentrations and sCD163/sTWEAK ratio were 11. 0% and 15. 0% higher, respectively, (P<0. 001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0. 001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0. 0001 and; P = 0. 002 for coffee and red wine intake, respectively). High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes.
Ajuts:	Ministerio de Ciencia e Innovación PI11/00049 Ministerio de Ciencia e Innovación PI11/02755
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 9 (june 2014) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0101250
PMID: 24978196

8 p, 222.0 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats