Exhaled Nitric Oxide Fraction as an Add-On to ACQ-7 for Not Well Controlled Asthma Detection
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau)
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau)
Muñoz, Ana María (Institut d'Investigació Biomèdica Sant Pau)
Fortuna Gutiérrez, Ana Mª (Institut d'Investigació Biomèdica Sant Pau)
Crespo Lessmann, Astrid (Institut d'Investigació Biomèdica Sant Pau)
Murio, Cristina (Chiesi España, L'Hospitalet de Llobregat)
Palomino, Rosa (GOC Networking, Barcelona)
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	The measurement of fractional nitric oxide concentration in exhaled breath (FeNO), a noninvasive indicator of airway inflammation, remains controversial as a tool to assess asthma control. Guidelines currently limit asthma control assessment to symptom and spirometry based appraisals such as the Asthma Control Questionnaire-7 (ACQ-7). We aimed at determining whether adding FeNO to ACQ-7 improves current asthma clinical control assessment, through enhanced detection of not well controlled asthma. Asthmatic subjects, classified as not well controlled as per ACQ-7 on regular clinical practice, were included in a prospective, multicenter fashion, and had their maintenance treatment adjusted on visit 1. On follow-up (visit 2) four weeks later, the subjects were reevaluated as controlled or not well controlled using ACQ-7 versus a combination of FeNO and ACQ-7. Out of 381 subjects enrolled, 225 (59. 1%) had not well controlled asthma on visit 2 as determined by ACQ-7, and 264 (69. 3%) as per combined FeNO and ACQ-7. The combination of FeNO to ACQ-7 increased by 14. 8% the detection of not well controlled asthma following maintenance therapy adjustment. The addition of FeNO to ACQ-7 increased the detectability of not well controlled asthma upon adjustment of maintenance therapy. Adding a measure of airway inflammation to usual symptom and spirometry based scores increases the efficacy of current asthma clinical control assessment.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 8 (october 2013) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0077085
PMID: 24204742

6 p, 239.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles