Molecular Markers for Prostate Cancer in Formalin-Fixed Paraffin-Embedded Tissues
Sequeiros, Tamara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
García, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Montes, Melania (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rigau, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca)
de Torres, Inés (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Morote Robles, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Reventós Puigjaner, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Doll, Andreas (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2013
Resum:	Prostate cancer (PCa) is the most frequently diagnosed type of cancer in developed countries. The decisive method of diagnosis is based on the results of biopsies, morphologically evaluated to determine the presence or absence of cancer. Although this approach leads to a confident diagnosis in most cases, it can be improved by using the molecular markers present in the tissue. Both miRNAs and proteins are considered excellent candidates for biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues, due to their stability over long periods of time. In the last few years, a concerted effort has been made to develop the necessary tools for their reliable measurement in these types of samples. Furthermore, the use of these kinds of markers may also help in establishing tumor grade and aggressiveness, as well as predicting the possible outcomes in each particular case for the different treatments available. This would aid clinicians in the decision-making process. In this review, we attempt to summarize and discuss the potential use of microRNA and protein profiles in FFPE tissue samples as markers to better predict PCa diagnosis, progression, and response to therapy.
Ajuts:	Ministerio de Ciencia e Innovación PI11/02486 Ministerio de Ciencia e Innovación CP10/00355 Ministerio de Ciencia e Innovación PS 09/00496 Ministerio de Ciencia e Innovación RD06/0036/0035 Ministerio de Economía y Competitividad IPT-2011-1569-010000 Ministerio de Economía y Competitividad IPT-2012-1311-300000 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR/00487
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	BioMed Research International, Vol. 2013 (november 2013) , ISSN 2314-6141

DOI: 10.1155/2013/283635
PMID: 24371818

16 p, 1.3 MB

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