Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
Gorriz, José Luis (Universitat de València)
Arroyo, David (Hospital General Universitario Gregorio Marañón)
D'Marco, Luis (Universitat de València)
Torra Balcells, Roser (Institut d'Investigació Biomèdica Sant Pau)
Tomás, Patricia (Universitat de València)
Puchades, María Jesús (Universitat de València)
Panizo, Nayara (Universitat de València)
Pantoja, Jonay (Universitat de València)
Montomoli, Marco (Universitat de València)
Llisterri, José Luis (Clinica Vallada, , Valencia)
Pallares-Carratala, Vicente (Universitat Jaume I)
Valdivielso, José Manuel (Universitat de Lleida)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and cardiovascular events (CVE) in ADPKD and their relations with asymptomatic CVD in CKD from other etiologies (CKDoe) and controls. We evaluated 2445 CKD patients (2010-2012). The information collected was: clinical, anthropometric and analytical parameters, treatments and CVD evaluation (intima-media thickness (IMT), atheromatous plaque presence and ankle-brachial index (ABI)). Laboratory, vital status, CVE and hospitalizations were collected for 4 years. ADPKD patients had a worse renal function and worst achievement of blood pressure, higher parathormone levels but lower proteinuria compared to CKDoe. ADPKD patients presented lower IMT values than other groups, however, an intermediate rate of pathologic ABI and atheromatous plaque was present. More than half of the patients received statins, achieving LDL-c levels < 100 only in 50 and 39. 8% of them (ADPKD and CKDoe respectively). The number of CVE during the follow-up period was low. In adjusted Cox regression model, ADPDK had the lowest occurrence of CVE of all three groups (HR:0. 422, 95%CI 0. 221-0. 808, p = 0. 009). ADPKD patients show intermediate control rates of CVD. A better control of CVD risk seems to be related with a lower load of CVD compared to other groups, which may lead in the long term to a better prognosis. Further investigation is necessary to determine cardiovascular prognosis in ADPKD. The online version contains supplementary material available at 10. 1186/s12882-021-02313-1.
Grants:	Instituto de Salud Carlos III RD12/0021 Instituto de Salud Carlos III PS10/00946 Instituto de Salud Carlos III RD16/0009 Instituto de Salud Carlos III PI15/01824 Instituto de Salud Carlos III PI18/00362
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Autosomal dominant polycystic kidney disease ; Chronic kidney disease ; Cardiovascular disease ; Nephropathy
Published in:	BMC Nephrology, Vol. 22 (march 2021) , ISSN 1471-2369

DOI: 10.1186/s12882-021-02313-1
PMID: 33765945

10 p, 871.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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