Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
Marazuela, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pizarro Gonzálvez, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pancorbo, Olalla (Hospital Universitari Vall d'Hebron)
Rodríguez-Luna, David (Hospital Universitari Vall d'Hebron)
Vert, Carla (Hospital Universitari Vall d'Hebron)
Rovira, Alex (Hospital Universitari Vall d'Hebron)
Pujadas, Francesc (Hospital Universitari Vall d'Hebron)
Freijo, M. Mar (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Martínez-Zabaleta, Maite (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Cardona, Pere-Joan (Hospital Universitari de Bellvitge)
Vera, Rocío (Hospital Universitario Ramón y Cajal (Madrid))
Lebrato-Hernández, Lucia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Arenillas, Juan F.. (Universidad de Valladolid)
Pérez-Sánchez, Soledad (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Montaner, Joan (Universidad de Sevilla)
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18. 6 months) and long-term (38. 5 ± 32. 9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.
Ajuts:	Instituto de Salud Carlos III PI17/00275 Instituto de Salud Carlos III PI20/00465 Ministerio de Economía y Competitividad RD16/0019/0021 Instituto de Salud Carlos III CPII17/00010
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Aquaporin 4 ; Cerebral amyloid angiopathy ; Intracerebral hemorrhage ; Magnetic resonance imaging markers ; Functional outcome
Publicat a:	Journal of clinical medicine, Vol. 10 (march 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10050989
PMID: 33801197

15 p, 1.0 MB

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