NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau)
Julian, Adrien (Poitiers University Hospital)
Page, Guylène (University of Poitiers)
Ragot, Stéphanie (Poitiers University Hospital)
Lehmann, Sylvain (Université de Montpellier)
Paccalin, Marc (Poitiers University Hospital)

Date:	2021
Abstract:	Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a consensus signature, which is mainly due to the heterogeneity of the methods used or the cohort. The present work aims to describe the potential informativity of peripheral inflammation in AD, focusing in particular on the potential association between the level of plasma neurofilament light (NFL), peripheral inflammation (by quantifying IL-1β, IL-6, TNFα, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales) through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU Poitiers, Pr M. Paccalin). Our results show for the first time a strong correlation between plasma NFL and TNF-R1 at each time of follow-up (baseline, 12 and 24 months), thus opening an interesting perspective for the prognosis of AD patients.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Diseases ; Neurology
Published in:	Scientific reports, Vol. 11 (may 2021) , ISSN 2045-2322

DOI: 10.1038/s41598-021-89749-5
PMID: 33986423

7 p, 798.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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