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| Página principal > Artículos > Artículos publicados > The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
(Hospital Clínico San Carlos (Madrid)) (Hospital Universitario Ramón y Cajal (Madrid)) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Complejo Hospitalario de Navarra) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Instituto de Investigación Sanitaria de Aragón) (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) (Institut d'Investigació Biomèdica Sant Pau) (Universitat de Barcelona. Institut de Neurociències) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut Hospital del Mar d'Investigacions Mèdiques) (Instituto de Investigación Sanitaria de Navarra) (Centro de Investigación Biomédica en Red de Salud Mental) (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) (Hospital General Universitario Gregorio Marañón) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Hospital General Universitario Gregorio Marañón)| Fecha: | 2021 |
| Resumen: | Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0. 59), poorer functioning (d = 0. 82), lower remission (61% vs. 81. 1%), and clinical recovery (34. 1% vs. 62. 2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup. |
| Ayudas: | Instituto de Salud Carlos III PI17/00481 Instituto de Salud Carlos III PI20/00216 Instituto de Salud Carlos III CD20/00177 Instituto de Salud Carlos III RYC-2017-23144 Ministerio de Ciencia e Innovación 24628 Ministerio de Ciencia e Innovación PI15/00283 Ministerio de Ciencia e Innovación PI18/00805 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1365 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/00357 |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | Psychosis ; First-episode ; Premorbid intelligence ; Age at onset ; Functional outcome ; Remission ; Recovery ; Heterogeneity ; Subgroup |
| Publicado en: | Journal of clinical medicine, Vol. 10 (june 2021) , ISSN 2077-0383 |
