visitant ::
identificació
|
|||||||||||||||
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español |
Pàgina inicial > Articles > Articles publicats > The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
Data: | 2021 |
Resum: | Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0. 59), poorer functioning (d = 0. 82), lower remission (61% vs. 81. 1%), and clinical recovery (34. 1% vs. 62. 2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup. |
Ajuts: | Instituto de Salud Carlos III PI17/00481 Instituto de Salud Carlos III PI20/00216 Instituto de Salud Carlos III CD20/00177 Instituto de Salud Carlos III RYC-2017-23144 Ministerio de Ciencia e Innovación 24628 Ministerio de Ciencia e Innovación PI15/00283 Ministerio de Ciencia e Innovación PI18/00805 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1365 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/00357 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Psychosis ; First-episode ; Premorbid intelligence ; Age at onset ; Functional outcome ; Remission ; Recovery ; Heterogeneity ; Subgroup |
Publicat a: | Journal of clinical medicine, Vol. 10 (june 2021) , ISSN 2077-0383 |
19 p, 3.4 MB |