Cross-species comparisons of nanoparticle interactions with innate immune systems : a methodological review
Swartzwelter, Benjamin (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
Mayall, Craig (University of Liubljana. Department of Biology)
Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica (Palerm, Itàlia))
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia)
Ferrari, Eleonora (ZMBP Eberhard-Karls University Tübingen. Center for Plant Molecular Biology)
Hernadi, Szabolcs (Cardiff University. School of Biosciences)
Michelini, Sara (Paris-Lodron University Salzburg. Department of Biosciences)
Navarro Pacheco, Natividad Isabel (Institute of Microbiology of the Czech Academy of Sciences)
Prinelli, Alessandra (AvantiCell Science, Ltd.)
Swart, Elmer (UK Centre for Ecology and Hydrology (Wallingford, Regne Unit))
Auguste, Manon (Università degli Studi di Genova. Dipartimento di Ambiente terrestre e scienze della vita)

Data:	2021
Resum:	Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). However, differences of methodology and procedure between diverse species and models make comparison of innate immune responses to NPs between organisms difficult in many cases. To this aim, this review provides an overview of suitable methods and assays that can be used to measure NP immune interactions across species in a multidisciplinary approach. The first part of this review describes the main innate immune defense characteristics of the selected models that can be associated to NPs exposure. In the second part, the different modes of exposure to NPs across models (considering isolated cells or whole organisms) and the main endpoints measured are discussed. In this synergistic perspective, we provide an overview of the current state of important cross-disciplinary immunological models to study NP-immune interactions and identify future research needs. As such, this paper could be used as a methodological reference point for future nano-immunosafety studies.
Ajuts:	European Commission 671881
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Environmental models ; Human cells ; Innate immunity ; Markers ; NPs testing
Publicat a:	Nanomaterials, Vol. 11, issue 6, art. 1528 (June 2021) , ISSN 2079-4991

DOI: 10.3390/nano11061528
PMID: 34207693

32 p, 4.2 MB

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