Serum Contactin-1 in CIDP
Wieske, Luuk (Amsterdam UMC, Location AMC, Amsterdam, the Netherlands)
Martín-Aguilar, Lorena (Institut d'Investigació Biomèdica Sant Pau)
Fehmi, Janev (John Radcliffe Hospital (Oxford, Regne Unit))
Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau)
Koel-Simmelink, Marleen J. A. (Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands)
Chatterjee, Madhurima (Amsterdam UMC, Location VU Medical Center, Amsterdam, the Netherland)
van Lierop, Zoë (Amsterdam UMC, Location VU Medical Center, Amsterdam, the Netherland)
Killestein, Joep (Amsterdam UMC, Location VU Medical Center, Amsterdam, the Netherland)
Verhamme, Camiel (Amsterdam UMC, Location AMC, Amsterdam, the Netherlands)
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Rinaldi, Simon (John Radcliffe Hospital (Oxford, Regne Unit))
Teunissen, Charlotte E. (Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands)
Eftimov, Filip (Amsterdam UMC, Location AMC, Amsterdam, the Netherlands)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	To investigate whether serum levels of contactin-1, a paranodal protein, correlate with paranodal injury as seen in patients with CIDP with antibodies targeting the paranodal region. Serum contactin-1 levels were measured in 187 patients with CIDP and 222 healthy controls. Paranodal antibodies were investigated in all patients. Serum contactin-1 levels were lower in patients (N = 41) with paranodal antibodies compared with patients (N = 146) without paranodal antibodies (p < 0. 01) and showed good discrimination between these groups (area under the curve 0. 84; 95% CI: 0. 76-0. 93). These findings suggest that serum contactin-1 levels have the potential to serve as a possible diagnostic biomarker of paranodal injury in CIDP. This study provides class II evidence that serum contactin-1 levels can discriminate between patients with CIDP with or without paranodal antibodies with a sensitivity of 71% (95% CI: 56%-85%) and a specificity of 97% (95% CI: 83%-100%).
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Neurology® neuroimmunology & neuroinflammation, Vol. 8 (july 2021) , ISSN 2332-7812

DOI: 10.1212/NXI.0000000000001040
PMID: 34285092

5 p, 211.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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