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| Home > Articles > Published articles > TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism |
| Home > Articles > Published articles > TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism |
(Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) (Institut d'Investigació Biomèdica Sant Pau) (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) (Institut d'Investigació Biomèdica Sant Pau) (Universitat de Barcelona) (Institut d'Investigació Biomèdica Sant Pau) (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)| Date: | 2022 |
| Abstract: | Background: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (γBB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54 VTE patients and 57 controls. Platelet function, platelet hyperreactivity, platelet adhesiveness, thrombosis-associated parameters, and thrombin generation parameters were studied. Plasma TMAO, γBB, and TML determination was performed using an ultra-high-performance liquid chromatography system coupled with mass spectrometry. Results: No differences were found for TMAO, γBB, or TML concentrations between controls and VTE patients. In thrombin generation tests, TMAO, γBB, and TML showed a positive correlation with lag time and time to peak. TMAO, γBB, and TML negatively correlated with peak height. No significant differences were observed regarding TMAO, γBB, and TML concentrations between the two blood withdrawals, nor when the control and VTE patients were analyzed separately. No correlation was observed between these gut metabolites and platelet function parameters. Conclusions: No differences were found regarding TMAO, γBB, and TML concentrations between the control and VTE groups. Some correlations were found; however, they were mild or went in the opposite direction of what would be expected if TMAO and its derivatives were related to VTE risk. |
| Grants: | Agencia Estatal de Investigación RYC-201722879 Instituto de Salud Carlos III PI18-00164 Instituto de Salud Carlos III PI21-00140 Instituto de Salud Carlos III PI12/00612 Instituto de Salud Carlos III PI15/00269 Instituto de Salud Carlos III PI18/00434 Instituto de Salud Carlos III PI19-00136 Instituto de Salud Carlos III CM20/00033 Instituto de Salud Carlos III CPII18/00004 Ministerio de Ciencia e Innovación RED2018-102799-T |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Trimethylamine N-oxide ; TMAO ; γBB ; TML ; Liquid chromatography-mass spectrometry ; Venous thromboembolism |
| Published in: | Journal of clinical medicine, Vol. 11 (march 2022) , ISSN 2077-0383 |
