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| Home > Articles > Published articles > A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood |
(Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) (Araba Unibertsitate Ospitalea) (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) (Institut d'Investigació Biomèdica Sant Pau) (FIDMAG Germanes Hospitalàries Research Foundation) (Institut de Recerca Sant Joan de Déu) (Instituto de Investigación Sanitaria de Aragón) (Instituto de Investigación Sanitaria de Navarra) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Institut d'Investigació Biomèdica Sant Pau) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Institut Hospital del Mar d'Investigacions Mèdiques)| Date: | 2021 |
| Abstract: | Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. A total of 91 participants of the 2EPs project formed the sample for baseline gene expression analysis. Of these, 67 provided biological samples at follow-up (36 after 3 years and 31 at relapse). Gene expression was assessed using the Clariom S Human Array. Weighted gene co-expression network analysis was applied to identify modules of co-expressed genes and to analyze their preservation after 3 years of follow-up or at relapse. Among the 25 modules identified, one module was semi-conserved at relapse (DarkTurquoise) and was enriched with risk genes for schizophrenia, showing a dysregulation of the TCF4 gene network in the module. Two modules were semi-conserved both at relapse and after 3 years of follow-up (DarkRed and DarkGrey) and were found to be biologically associated with protein modification and protein location processes. Higher expression of DarkRed genes was associated with higher risk of suffering a relapse and early appearance of relapse (p = 0. 045). Our findings suggest that a dysregulation of the TCF4 network could be an important step in the biological process that leads to relapse and suggest that genes related to the ubiquitin proteosome system could be potential biomarkers of relapse. |
| Grants: | Instituto de Salud Carlos III PI08-0208 Instituto de Salud Carlos III PI11-00325 Instituto de Salud Carlos III PI14-00612 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1562 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1355 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Gene Expression ; Gene Expression Profiling ; Humans ; Longitudinal Studies ; Recurrence ; Schizophrenia |
| Published in: | Translational psychiatry, Vol. 11 Núm. 1 (december 2021) , p. 539, ISSN 2158-3188 |
