Web of Science: 4 cites, Scopus: 4 cites, Google Scholar: cites,
Leishmania infantum Specific Humoral and Cellular Immune Responses in Cats and Dogs : A Comparative Cross-Sectional Study
Priolo, Vito (Università di Messina. Dipartimento di Scienze Veterinarie)
Martínez-Orellana, Pamela (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pennisi, Maria Grazia (Università di Messina. Dipartimento di Scienze Veterinarie)
Raya-Bermúdez, Ana Isabel (Universidad de Córdoba. Facultad de Medicina Veterinaria)
Jurado-Tarifa, Estefanía (Universidad de Córdoba. Facultad de Medicina Veterinaria)
Masucci, Marisa (Università di Messina. Dipartimento di Scienze Veterinarie)
Donato, Giulia (Università di Messina. Dipartimento di Scienze Veterinarie)
Bruno, Federica (Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri". Centro di Referenza Nazionale per la Leishmaniosi (CReNaL))
Castelli, Germano (Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri". Centro di Referenza Nazionale per la Leishmaniosi (CReNaL))
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Data: 2022
Resum: The role of the cat as a reservoir of Leishmania infantum and the characteristics of the immune response to this infection remains limited, contrary to the dog. This study aimed to compare the rate of L. infantum infection and parasite-specific humoral and cell-mediated immune responses in cats and dogs living in an area endemic to canine leishmaniosis (Córdoba, Spain). About one-third of the dogs and cats studied were positive for at least one molecular or serological diagnostic test. The immunopathogenesis of L. infantum infection in cats showed similarities when compared to dogs, although the parasite-specific immune response level in dogs was generally higher than in cats. This study shows that stray cats are exposed to L. infantum infection similarly to dogs in endemic areas, are able to mount a specific anti -Leishmania humoral and cell-mediated immune response as dogs, and can contribute to the endemicity of infection. Dogs are the main reservoir of Leishmania infantum and display different immunological patterns correlating with the progression of infection to disease. Data about feline L. infantum adaptive immune response are scant. This study aimed to compare the prevalence and immune response in cats and dogs from the same endemic area of canine leishmaniosis. Stray cats (109) and rescued dogs (59) from Córdoba (Spain) were enrolled. Data about their exposure to L. infantum were analyzed by detection of parasite DNA, measurements of Leishmania- specific interferon-γ (whole blood assay in 57 cats and 29 dogs), and antibodies (enzyme-linked immunosorbent assay and immunofluorescence antibody test). An overall L. infantum prevalence of 30. 5% in dogs and 30% in cats were found according to serology and PCR tests. Prevalence was 44. 8% in dogs and 35. 1% in cats tested also for interferon-γ production. Dogs showed higher anti- L. infantum antibody levels compared to cats. More than one-third of cats had contact with or were infected by L. infantum and they may contribute to the endemicity of leishmaniosis in the investigated region. The immunopathogenesis of feline L. infantum infection has similarities with dogs but cats show a lower level of adaptive immune response compared to dogs.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Leishmaniosis ; Feline ; Canine ; IFN-γ ; Whole blood assay ; PCR ; Feline immunodeficiency virus ; Prevalence ; ELISA ; IFAT
Publicat a: Veterinary Sciences, Vol. 9 (september 2022) , ISSN 2306-7381

DOI: 10.3390/vetsci9090482
PMID: 36136697


14 p, 342.7 KB

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 Registre creat el 2022-09-29, darrera modificació el 2023-04-27



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