Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
Martínez-Serrat, Maria (Universitat Autònoma de Barcelona. Institut de Neurociències)
Martínez-Martel, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Coral-Pérez, Santiago (Universitat Autònoma de Barcelona. Institut de Neurociències)
Bai, Xue (Universitat Autònoma de Barcelona. Institut de Neurociències)
Batallé Melgarejo, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències)
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Institut d'Investigació Biomèdica Sant Pau

Fecha:	2022
Resumen:	Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. Recent studies have reported the protective role of molecular hydrogen (H) in different diseases including neurological disorders, such as Alzheimer's as well as its antidepressant activities in animals with chronic stress. This study explored the effects of treatment with hydrogen-rich water (HRW) in male mice with neuropathic pain induced by the chronic constriction of the sciatic nerve (CCI) and the accompanying affective deficits. The likely pathways implied in the HRW analgesic activity, as well as the interaction between heme oxygenase 1 (HO-1) enzyme and H during neuropathic pain were also studied. The results showed: (i) the inhibitory effects of the repetitive treatment with HRW on the allodynia and hyperalgesia provoked by CCI; (ii) the anxiolytic and antidepressant actions of HRW in animals with neuropathic pain; (iii) the contribution of the antioxidant enzymes (HO-1 and NAD(P)H: quinone oxidoreductase 1) and the ATP sensitive potassium channels in the painkiller activities of HRW during neuropathic pain; (iv) a positive interaction between the HO-1 and H systems in inhibiting the CCI-induced neuropathy; and (v) the antioxidant, antinociceptive, anti-inflammatory and/or antiapoptotic features of HRW treatment in the dorsal root ganglia and/or amygdala of sciatic nerve-injured mice. This study demonstrates new protective actions of H and suggests that treatment with HRW might be an interesting therapeutic strategy for chronic neuropathic pain and its associated mood disorders.
Ayudas:	Instituto de Salud Carlos III PI18/00645 Instituto de Salud Carlos III PI21/00592
Nota:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Analgesia ; Apoptosis ; Hydrogen-rich water ; Inflammation ; Molecular hydrogen ; Neuropathic pain ; Oxidative stress
Publicado en:	Antioxidants, Vol. 11, Issue 9 (September 2022) , art. 1826, ISSN 2076-3921

DOI: 10.3390/antiox11091826
PMID: 36139900

19 p, 4.6 MB

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