Toward Next Generation Lateral Flow Assays : Integration of Nanomaterials
Sena-Torralba, Amadeo (Institut Català de Nanociència i Nanotecnologia)
Álvarez Diduk, Ruslan (Institut Català de Nanociència i Nanotecnologia)
Parolo, Claudio (Institut de Salut Global de Barcelona)
Piper, Andrew (Institut Català de Nanociència i Nanotecnologia)
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)

Date:	2022
Abstract:	Lateral flow assays (LFAs) are currently the most used point-of-care sensors for both diagnostic (e. g. , pregnancy test, COVID-19 monitoring) and environmental (e. g. , pesticides and bacterial monitoring) applications. Although the core of LFA technology was developed several decades ago, in recent years the integration of novel nanomaterials as signal transducers or receptor immobilization platforms has brought improved analytical capabilities. In this Review, we present how nanomaterial-based LFAs can address the inherent challenges of point-of-care (PoC) diagnostics such as sensitivity enhancement, lowering of detection limits, multiplexing, and quantification of analytes in complex samples. Specifically, we highlight the strategies that can synergistically solve the limitations of current LFAs and that have proven commercial feasibility. Finally, we discuss the barriers toward commercialization and the next generation of LFAs.
Grants:	Instituto de Salud Carlos III AC21_2/00044 European Commission 825694 European Commission 881603 Ministerio de Ciencia e Innovación SEV-2017-0706 Agencia Estatal de Investigación PID2021-124795NB-I00 Ministerio de Economía y Competitividad FJC2020-043927-I European Commission 795635 Ministerio de Ciencia e Innovación CEX2018-000806-S
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Assays ; Colorimetry ; Infrared light ; Metal nanoparticles ; Nanoparticles
Published in:	Chemical Reviews, Vol. 122, Issue 18 (September 2022) , p. 14881-14910, ISSN 1520-6890

DOI: 10.1021/acs.chemrev.1c01012
PMID: 36067039

30 p, 21.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles