Role of Mesenchymal Stem/Stromal Cells in Coagulation
Guillamat-Prats, Raquel (Institut Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Mesenchymal stem/stromal cells (MSCs) are widely used in disease models in order to control several phases in the response to injuries, immune reaction, wound healing, and regeneration. MSCs can act upon both the innate and adaptive immune systems and target a broad number of functions, such as the secretion of cytokines, proteolytic enzymes, angiogenic factors, and the regulating of cell proliferation and survival. The role of MSCs in coagulation has been less studied. This review evaluates the properties and main functions of MSCs in coagulation. MSCs can regulate coagulation in a wide range of pathways. MSCs express and release tissue factors (TF), one of the key regulators of the extrinsic coagulation pathways; MSCs can trigger platelet production and contribute to platelet activation. Altogether, MSCs seem to have a pro-thrombotic role and their superior characterization prior to their administration is necessary in order to prevent adverse coagulation events.
Ajuts:	Instituto de Salud Carlos III CP20/00133 Instituto de Salud Carlos III 2019/002067
Nota:	This study was funded by Instituto de Salud Carlos III through the Miguel Servet, contract "CP20/00133 (ISCIII-AES-2019/002067) "and co-funded by the European Regional Development Fund/European Social Fund "A way to make Europe"/"Investing in your future".
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	International journal of molecular sciences, Vol. 23 Núm. 18 (september 2022) , p. 10393, ISSN 1422-0067

DOI: 10.3390/ijms231810393
PMID: 36142297

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