Genetic and phenotypic characterisation of HIV-associated aggressive B-cell non-Hodgkin lymphomas, which do not occur specifically in this population : diagnostic and prognostic implications
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muñoz-Marmol, Ana Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muncunill Farreny, Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Montoto, Silvia (Centre for Haemato-Oncology. Barts Cancer Institute. Queen Mary University of London)
Gribben, John G. (Centre for Haemato-Oncology. Barts Cancer Institute. Queen Mary University of London)
Calaminici, Maria (Centre for Haemato-Oncology. Barts Cancer Institute. Queen Mary University of London)
Martinez, Antonio (Hospital Clínic i Provincial de Barcelona)
Veloza, Luis (Hospital Clínic i Provincial de Barcelona)
Martínez-Trillos, Alejandra (Hospital Clínic i Provincial de Barcelona)
Aldámiz-Echevarría, T (Hospital General Universitario Gregorio Marañón)
Menarguez, Javier (Hospital General Universitario Gregorio Marañón)
Terol, Maria José (Hospital Clínic Universitari (València))
Ferrandez, Antonio (Hospital Clínic Universitari (València))
Alcoceba, Miguel (Hospital Universitario de Salamanca)
Briones Meijide, Javier (Institut d'Investigació Biomèdica Sant Pau)
Gonzalez-Barca, Eva (Hospital Duran i Reynals (Hospitalet del Llobregat))
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge)
Muntañola, Ana (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Moraleda, José Maria (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron)
Abella Monreal, Eugenia (Hospital del Mar (Barcelona, Catalunya))
Colomo, Luis (Hospital del Mar (Barcelona, Catalunya))
García-Ballesteros, Carlos (Hospital Arnau de Vilanova (València))
Garcia-Caro, Montserrat (Hospital de Mataró. Consorci Sanitari del Maresme)
Sancho, Juan-Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ribera, José Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)

Fecha:	2022
Resumen:	The frequency of aggressive subtypes of B-cell non-Hodgkin lymphoma (B-NHL), such as high-grade B-cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangement (HGBL-DH/TH) or Burkitt-like lymphoma (BL) with 11q aberration, is not well known in the HIV setting. We aimed to characterise HIV-associated aggressive B-NHL according to the 2017 WHO criteria, and to identify genotypic and phenotypic features with prognostic impact. Seventy-five HIV-associated aggressive B-NHL were studied by immunohistochemistry (CD10, BCL2, BCL6, MUM1, MYC, and CD30), EBV-encoded RNAs (EBERs), and fluorescence in situ hybridisation (FISH) to evaluate the status of the MYC, BCL2, and BCL6 genes and chromosome 11q. The 2017 WHO classification criteria and the Hans algorithm, for the cell-of-origin classification of diffuse large B-cell lymphomas (DLBCL), were applied. In DLBCL cases, the frequencies of MYC and BCL6 rearrangements (14. 9 and 27. 7%, respectively) were similar to those described in HIV-negative patients, but BCL2 rearrangements were infrequent (4. 3%). MYC expression was identified in 23. 4% of DLBCL cases, and coexpression of MYC and BCL2 in 13. 0%, which was associated with a worse prognosis. As for BL cases, the expression of MUM1 (30. 4%) conferred a worse prognosis. Finally, the prevalence of HGBL-DH/TH and BL-like with 11q aberration are reported in the HIV setting. The phenotypic and genotypic characteristics of HIV-associated aggressive B-NHL are similar to those of the general population, except for the low frequency of BCL2 rearrangements in DLBCL. MYC and BCL2 coexpression in DLBCL, and MUM-1 expression in BL, have a negative prognostic impact on HIV-infected individuals.
Ayudas:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR288 Instituto de Salud Carlos III PI19/01588
Nota:	Altres ajuts: acords transformatius de la UAB
Nota:	Altres ajuts: Gilead Sciences S.L. (GLD19/00121); Josep Carreras International Foundation; "la Caixa" Foundation
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Genetics ; Phenotype ; HIV ; Lymphoma
Publicado en:	Histopathology, 2022 , ISSN 1365-2559

DOI: 10.1111/his.14798
PMID: 36109172

15 p, 1.3 MB

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