Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer
De Schepper, Maxim (KU Leuven)
Vincent-Salomon, Anne (PSL Research University)
Christgen, Matthias (Hannover Medical School)
Van Baelen, Karen (KU Leuven)
Richard, François (KU Leuven)
Tsuda, Hitoshi (National Defense Medical College Hospital)
Kurozumi, Sasagu (International University of Health and Welfare. Department of Breast Surgery)
Brito, Maria Jose (Champalimaud Foundation (Portugal))
Cserni, Gabor (University of Szeged)
Schnitt, Stuart (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Larsimont, Denis (Université Libre de Bruxelles. Department of Pathology)
Kulka, Janina (Semmelweis University. Department of Pathology, Forensic and Insurance Medicine)
Fernández, Pedro Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez-Martínez, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Olivar, Ana Aula (Hospital Universitari de Girona Doctor Josep Trueta)
Melendez, Cristina (Hospital Universitari de Girona Doctor Josep Trueta)
Van Bockstal, Mieke (Cliniques universitaires Saint-Luc Bruxelles)
Kovacs, Aniko (Sahlgrenska University Hospital. Department of Clinical Pathology)
Varga, Zsuzsanna (University Hospital Zurich (Suïssa))
Wesseling, Jelle (The Netherlands Cancer Institute (Amsterdam, Països Baixos))
Bhargava, Rohit (UPMC Magee-Womens Hospital. Department of Pathology)
Boström, Pia (University of Turku. Department of Pathology)
Franchet, Camille (Institut Universitaire du Cancer Toulouse-Oncopole)
Zambuko, Blessing (University of Botswana. Department of Pathology)
Matute, Gustavo (Universidad Pontificia Bolivariana)
Mueller, Sophie (Hannover Medical School)
Berghian, Anca (Centre Henri Becquerel. Department of Biopathology)
Rakha, Emad (Nottingham University Hospitals NHS Trust (Regne Unit))
van Diest, Paul J. (University Medical Center Utrecht. Department of Pathology)
Oesterreich, Steffi (Magee-Womens Research Institute (Estats Units d'Amèrica))
Derksen, Patrick W. B. (University Medical Center Utrecht. Department of Pathology)
Floris, Giuseppe (University Hospitals Leuven (Bèlgica))
Desmedt, Christine (KU Leuven)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Invasive lobular carcinoma (ILC) represents the second most common subtype of breast cancer (BC), accounting for up to 15% of all invasive BC. Loss of cell adhesion due to functional inactivation of E-cadherin is the hallmark of ILC. Although the current world health organization (WHO) classification for diagnosing ILC requires the recognition of the dispersed or linear non-cohesive growth pattern, it is not mandatory to demonstrate E-cadherin loss by immunohistochemistry (IHC). Recent results of central pathology review of two large randomized clinical trials have demonstrated relative overdiagnosis of ILC, as only ~60% of the locally diagnosed ILCs were confirmed by central pathology. To understand the possible underlying reasons of this discrepancy, we undertook a worldwide survey on the current practice of diagnosing BC as ILC. A survey was drafted by a panel of pathologists and researchers from the European lobular breast cancer consortium (ELBCC) using the online tool SurveyMonkey®. Various parameters such as indications for IHC staining, IHC clones, and IHC staining procedures were questioned. Finally, systematic reporting of non-classical ILC variants were also interrogated. This survey was sent out to pathologists worldwide and circulated from December 14, 2020 until July, 1 2021. The results demonstrate that approximately half of the institutions use E-cadherin expression loss by IHC as an ancillary test to diagnose ILC and that there is a great variability in immunostaining protocols. This might cause different staining results and discordant interpretations. As ILC-specific therapeutic and diagnostic avenues are currently explored in the context of clinical trials, it is of importance to improve standardization of histopathologic diagnosis of ILC diagnosis.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Pathology ; Breast cancer
Publicat a:	Modern Pathology, Vol. 35 (august 2022) , p. 1812-1820, ISSN 1530-0285

DOI: 10.1038/s41379-022-01135-2
PMID: 35922548

9 p, 1.2 MB

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