Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19 : A Cross-Sectional Study
Arroyo, Juan Antonio (Institut d'Investigació Biomèdica Sant Pau)
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau)
Vlacho, Bogdan (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Ponte, Paola (Institut d'Investigació Biomèdica Sant Pau)
Roman, Eva (Institut d'Investigació Biomèdica Sant Pau)
Navas, Elena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Llauradó, G. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Franch-Nadal, J. (Primary Health Care Center Raval Sud)
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Aim: The study aim was to assess the association of vitamin D supplementation before hospital admission and severe outcomes in subjects admitted for COVID-19. Methods: We performed a cross-sectional analysis of pseudonymised medical record data from subjects admitted to the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The composite primary study outcome was defined as death and/or invasive mechanical ventilation (IMV). Association between risk factors and study outcomes was evaluated by bivariate analysis, followed by logistic regression analysis. Results: In total, 1,267 persons were hospitalised during the observation period. Overall, 14. 9% of the subjects were on active vitamin D supplementation treatment before admission. The subjects in the vitamin D group were significantly older than subjects without vitamin D supplementation. We observed higher rates of the primary outcome (death and/or IMV) among the persons with previous use of vitamin D (30. 1 vs. 22. 9% in those not receiving treatment). In the bivariate analysis, previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR): 1. 45 95% CI: 1. 03; 2. 04]; however, after adjustment for other risk factors this association disappeared (OR: 1. 09 95%CI: 0. 65; 1. 81). Conclusion: We did not find an association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19. The age and the burden of age-associated comorbidities were independently associated with the in-hospital events.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; Hospitalisation ; Mortality ; Invasive mechanic ventilation ; Vitamin D
Published in:	Frontiers in Public Health, Vol. 9 (september 2021) , p. 758347, ISSN 2296-2565

DOI: 10.3389/fpubh.2021.758347
PMID: 34631653

9 p, 730.9 KB

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