(r)HDL in theranostics : How do we apply HDL's biology for precision medicine in atherosclerosis management?
Uribe, K.B. (Center for Cooperative Research in Biomaterials (CIC BiomaGUNE). Basque Research and Technology Alliance (BRTA))
Benito-Vicente, A. (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular)
Martin, C. (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular)
Blanco Vaca, Francisco (Institut d'Investigació Biomèdica Sant Pau)
Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	High-density lipoproteins (HDL) are key players in cholesterol metabolism homeostasis since they are responsible for transporting excess cholesterol from peripheral tissues to the liver. Imbalance in this process, due to either excessive accumulation or impaired clearance, results in net cholesterol accumulation and increases the risk of cardiovascular disease (CVD). Therefore, significant effort has been focused on the development of therapeutic tools capable of either directly or indirectly enhancing HDL-guided reverse cholesterol transport (RCT). More recently, in light of the emergence of precision nanomedicine, there has been renewed research interest in attempting to take advantage of the development of advanced recombinant HDL (rHDL) for both therapeutic and diagnostic purposes. In this review, we provide an update on the different approaches that have been developed using rHDL, focusing on the rHDL production methodology and rHDL applications in theranostics. We also compile a series of examples highlighting potential future perspectives in the field.
Grants:	Instituto de Salud Carlos III PI18/0164 Ministerio de Ciencia e Innovación PID2019-104367RB-100 Agencia Estatal de Investigación RYC-201722879
Note:	Altres ajuts: Eusko Jaurlaritza IT-1264-19 ; Euskal Herriko Unibertsitatea ; Fondo Europeo de Desarrollo Regional (FEDER)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Cardiovascular disease ; Cholesterol accumulation ; Cholesterol metabolism ; Cholesterol transport ; Future perspectives ; High-density lipoproteins ; Research interests ; Therapeutic tools ; Atherosclerosis ; Biology ; Cholesterol ; Humans ; Lipoproteins, HDL ; Precision Medicine
Published in:	Biomaterials science, Vol. 9 Núm. 9 (july 2021) , p. 3185-3208, ISSN 2047-4849

DOI: 10.1039/d0bm01838d
PMID: 33949389

24 p, 2.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles