First-line maintenance treatment in metastatic colorectal cancer (mCRC) : Quality and clinical benefit overview
Martín-Richard, Marta (Institut d'Investigació Biomèdica Sant Pau)
Tobeña, M. (Quironsalud Hospital)

Date:	2021
Abstract:	Different strategies of maintenance therapy (sequential CT, intermittent CT, intermittent CT and MAbs, or de-escalation MAbs monotherapy) after first-line treatment are undertaken. Many randomized clinical trials (RCT), which evaluated these approaches, suffer from incorrect design, heterogenous primary endpoints, inadequate size, and other methodology flaws. Drawing any conclusions becomes challenging and recommendations are mainly vague. We evaluated those studies from another perspective, focusing on the design quality and the clinical benefit measure with a more objective and accurate methodology. These data allowed a clearer and more exact overview of the statement in maintenance treatment.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Maintenance treatment ; Sequential ; Continuous ; Intermittent treatment
Published in:	Journal of clinical medicine, Vol. 10 Núm. 3 (january 2021) , p. 1-13, ISSN 2077-0383

DOI: 10.3390/jcm10030470
PMID: 33530547

13 p, 254.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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