Correlation between plateletworks® and pfa-100® for measuring platelet function before urgent surgery in patients with chronic antiplatelet therapy
Anaya, Rafael (Institut d'Investigació Biomèdica Sant Pau)
Rodriguez Prieto, Mireia (Institut d'Investigació Biomèdica Sant Pau)
Gil Sanchez, José María (Institut d'Investigació Biomèdica Sant Pau)
Vilalta, Noelia (Institut d'Investigació Biomèdica Sant Pau)
Merchán Galvis, Ángela María (Institut d'Investigació Biomèdica Sant Pau)
Moral, Victoria (Institut d'Investigació Biomèdica Sant Pau)
Mateo, José (Institut d'Investigació Biomèdica Sant Pau)
Martinez-Zapata, Maria José (Institut d'Investigació Biomèdica Sant Pau)

Date:	2021
Abstract:	Hemostasis is crucial for reducing bleeding during surgical procedures. The points-of-care based on the platelet function test could be useful to minimize the complications related to chronic antiplatelet therapy during surgery. The present study is aimed at comparing two point-of-care platelet function devices-Platelet Function Analyzer PFA-100® (Siemens Canada, Mississauga, ON, Canada) and Plateletworks® (Helena Laboratories, Beaumont, TX, USA). Our objective is to evaluate if they provide comparable and useful information to manage anti-aggregate patients before surgery. We included patients with a femoral fracture receiving chronic antiplatelet therapy and a median age of 89 years (range from 70 to 98). A platelet function evaluation was performed on all patients before surgery using both devices-Plateletworks® and PFA-100®. The correlation between Plateletworks® and PFA-100® was performed using Cohen's Kappa coefficient. Twenty consecutive patients par-ticipated in the trial; 16 patients were under treatment with 75 mg/day of clopidogrel, three with >300 mg/day of acetylsalicylic acid (ASA), and only one was in treatment with both antiplatelet agents. Cohen's Kappa coefficient was 0. 327 comparing PFA-100®-ADP (adenosine diphosphate) and Plateletworks® and, 0. 200 comparing PFA-100®-EPI (epinephrine) and Plateletworks®. In conclusion, we found a weak concordance comparing PFA-100® and Plateletworks®. This could partially be due to the advanced age of the included patients. However, given the limited sample size, more studies are necessary to confirm these results.
Note:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Biometa: Tecnologías y Sistemas SAL.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Platelet Function Test ; Point-of-care system ; Antiplatelet therapy ; Drug monitoring ; Urgent surgery
Published in:	Journal of clinical medicine, Vol. 10 Núm. 2 (february 2021) , p. 1-8, ISSN 2077-0383

DOI: 10.3390/jcm10020255
PMID: 33445597

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