The Potential of Sewage Sludge to Predict and Evaluate the Human Chemical Exposome
Gil-Solsona, Rubén (IDAEA Severo Ochoa (2020-2023))
Nika, Maria-Christina (Laboratory of Analytical Chemistry. Department of Chemistry. National and Kapodistrian University of Athens)
Bustamante, Mariona (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Villanueva, Cristina M. (Institut Hospital del Mar d'Investigacions Mèdiques)
Foraster, Maria (Universitat Ramon Llull)
Cosin-Tomas, Marta (Department of Human Genetics. Research Institute of the McGill University Health Center. McGill University)
Alygizakis, Nikiforos (Laboratory of Analytical Chemistry. Department of Chemistry. National and Kapodistrian University of Athens)
Gómez-Roig, María Dolores (Universitat de Barcelona)
Llurba, E (Institut d'Investigació Biomèdica Sant Pau)
Sunyer Deu, Jordi (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Thomaidis, Nikolaos S. (Laboratory of Analytical Chemistry. Department of Chemistry. National and Kapodistrian University of Athens)
Dadvand, Payam (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Gago-Ferrero, Pablo (IDAEA Severo Ochoa (2020-2023))

Data:	2021
Resum:	Chemicals are part of our daily lives, and we are exposed to numerous chemicals through multiple pathways. Relevant scientific evidence contributing to the regulation of hazardous chemicals require a holistic approach to assess simultaneous exposure to multiple compounds. Biomonitoring provides an accurate estimation of exposure to chemicals through very complex and costly sampling campaigns. Finding efficient proxies to predict the risk of chemical exposure in humans is an urgent need to cover large areas and populations at a reasonable cost. We conducted an exploratory study to characterize the human chemical exposome in maternal blood and placenta samples of a population-based birth cohort in Barcelona (2018-2021). Ultimate HRMS-based approaches were applied including wide-scope target, suspect, and nontarget screening. Forty-Two chemicals were identified including pesticides, personal care products, or industrial compounds, among others, in the range of ng/mL and ng/g. In parallel, sewage sludge from the wastewater treatment plants serving the residence areas of the studied population were also screened, showing correlations with the type and concentrations of chemicals found in humans. Our findings were suggestive for the potential use of sewage sludge as a proxy of the human exposure and its application in early warning systems to prevent bioaccumulation of hazardous chemicals.
Ajuts:	European Research Council 785994
Nota:	Altres ajuts: Fundació "La Caixa" (ID 100010434); fellowship code LCF/BQ/PR20/11770013; Barcelona Council (Expo-Bar); the Health Effects Institute (4959-RFPA15-1/18-1 FRONTIER).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Accurate estimation ; Biomonitoring ; Chemical exposure ; Daily lives ; Exposed to ; Hazardous chemicals ; Holistic approach ; Multiple pathways ; Sampling campaigns ; Scientific evidence
Publicat a:	Environmental Science and Technology Letters, Vol. 8 Núm. 12 (14 2021) , p. 1077-1084, ISSN 2328-8930

DOI: 10.1021/acs.estlett.1c00848
PMID: 35647215

8 p, 1.2 MB

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