Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients
Bermúdez-López, Marcelino (Institut de Recerca Biomèdica)
Perpiñan, H. (Conselleria de Sanitat Universal i Salut Pública. Generalitat Valenciana)
Amigó, Núria (Biosfer Teslab SL)
Castro, E. (Institut de Recerca Biomèdica)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Fernandez, E. (Institut de Recerca Biomèdica)
Valdivielso, José Manuel (Institut de Recerca Biomèdica)

Fecha:	2021
Resumen:	Background: Chronic kidney disease (CKD) patients have a high burden of atheromatous cardiovascular disease (ASCVD) not fully explained by traditional lipid parameters. Lipoprotein composition and subclass particle number information could improve ASCVD risk assessment. The objective of this study is to investigate the association of advanced lipoprotein parameters with the risk of atheromatosis in a subpopulation of the NEFRONA study. Methods: This was a cross-sectional study in 395 non-diabetic individuals (209 CKD and 186 non-diabetic and non-CKD) without statin therapy. Vascular ultrasound examination assessing 10 territories was combined with advanced lipoprotein testing performed by nuclear magnetic resonance spectroscopy. Logistic regression was used to estimate adjusted odds ratios (ORs) per 1 standard deviation increment. Results: Atheromatosis was more prevalent in CKD patients (33. 9% versus 64. 6%). After adjusting for age, gender, smoking habit and CKD stage, the amount of triglycerides (TGs) within low-density lipoprotein (LDL) lipoproteins was independently and positively associated with atheromatosis [OR 1. 33; 95% confidence interval (CI) 1. 03-1. 74; P = 0. 03]. Similarly, total and medium LDL particles (LDL-Ps) showed a positive association (OR 1. 29; 95% CI 1. 00-1. 68; P = 0. 05 and OR 1. 34; 95% CI 1. 04-1. 75; P = 0. 03, respectively). TG-loaded medium LDL-Ps were higher in CKD patients compared with controls and showed an adjusted OR of 1. 40 (95% CI 1. 09-1. 82; P = 0. 01) in non-diabetic patients (CKD and non-CKD individuals). In contrast, non-diabetic CKD patients showed a similar coefficient but the significance was lost (OR 1. 2; 95% CI 0. 8-1. 7; P = 0. 359). Conclusions: Non-diabetic CKD patients showed a higher amount of TG-loaded medium LDL-Ps compared with controls. These particles were independently associated with atheromatosis in non-diabetic patients.
Ayudas:	Instituto de Salud Carlos III RD16/ 0009/0011 Instituto de Salud Carlos III FIS PI18/00610 Ministerio de Ciencia, Innovación y Universidades IJC2018-037792-I
Nota:	Altres ajuts: IRBLleida Intramural Research Program; Fondo Europeo de Desarrollo Regional (FEDER).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Atherosclerosis ; Chronic kidney disease ; Dyslipidemia ; LDL cholesterol ; Lipoprotein subfractions ; Triglycerides
Publicado en:	Clinical Kidney Journal, Vol. 14 Núm. 12 (january 2021) , p. 2591-2599, ISSN 2048-8513

DOI: 10.1093/ckj/sfab113
PMID: 34950470

9 p, 534.5 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados