Management of localized muscle-invasive bladder cancer from a multidisciplinary perspective : Current position of the Spanish oncology genitourinary (Sogug)working group
Gomez-Caamaño, Antonio (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
García Vicente, Ana M. (Nuclear Medicine Department. University General Hospital)
Maroto Rey, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Rodríguez Antolín, Alfredo (Hospital Universitario 12 de Octubre (Madrid))
Sanz, Julián (Clínica Universidad de Navarra)
Vera González, María Almudena (Hospital Clínic Universitari (València))
Climent, Miguel Ángel (Fundació Institut Valencià d'Oncologia)

Date:	2021
Abstract:	This review presents challenges and recommendations on different aspects related to the management of patients with localized muscle-invasive bladder cancer (MIBC), which were discussed by a group of experts of a Spanish Oncology Genitourinary (SOGUG) Working Group within the framework of the Genitourinary Alliance project (12GU). It is necessary to clearly define which patients are candidates for radical cystectomy and which are candidates for undergoing bladder-sparing procedures. In older patients, it is necessary to include a geriatric assessment and evaluation of comorbidities. The pathological report should include a classification of the histopathological variant of MIBC, particularly the identification of subtypes with prognostic, molecular and therapeutic implications. Improvement of clinical staging, better definition of prognostic groups based on molecular subtypes, and identification of biomarkers potentially associated with maximum benefit from neoadjuvant chemotherapy are areas for further research. A current challenge in the management of MIBC is improving the selection of patients likely to be candidates for immunotherapy with checkpoint inhibitors in the neoadjuvant setting. Optimization of FDG-PET/CT reliability in staging of MIBC and the selection of patients is necessary, as well as the design of prospective studies aimed to compare the value of different imaging techniques in parallel.
Note:	Altres ajuts: Astra Zeneca.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Muscle-invasive bladder cancer ; Neoadjuvant chemotherapy ; Molecular subtypes ; Bladder preservation ; Radical cystectomy ; Immunotherapy ; Checkpoint inhibitors
Published in:	Current Oncology, Vol. 28 Núm. 6 (december 2021) , p. 5084-5100, ISSN 1718-7729

DOI: 10.3390/curroncol28060428
PMID: 34940067

17 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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