Combined analysis of miR-200 family and its significance for breast cancer
Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza)
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo della Sofferenza)
Dama, Elisa (Fondazione IRCCS Casa Sollievo della Sofferenza)
Pasculli, Barbara (Fondazione IRCCS Casa Sollievo della Sofferenza)
Rendina, Michelina (Fondazione IRCCS Casa Sollievo della Sofferenza)
Morritti, Maria Grazia (Fondazione IRCCS Casa Sollievo della Sofferenza)
Melocchi, Valentina (Fondazione IRCCS Casa Sollievo della Sofferenza)
Castelvetere, Marina (Fondazione IRCCS Casa Sollievo della Sofferenza)
Valori, Vanna Maria (Fondazione IRCCS Casa Sollievo della Sofferenza)
Ravaioli, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS)
Bravaccini, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS)
Ciuffreda, Luigi (Fondazione IRCCS Casa Sollievo della Sofferenza)
Graziano, Paolo (Fondazione IRCCS Casa Sollievo della Sofferenza)
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza)
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza)
Fazio, Vito Michele (Fondazione IRCCS Casa Sollievo della Sofferenza)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Bianchi, Fabrizio (Fondazione IRCCS Casa Sollievo della Sofferenza)
Parrella, Paola (Fondazione IRCCS Casa Sollievo della Sofferenza)

Data:	2021
Resum:	While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. Overall, miR-200 family was found upregulated in breast tumors with respect to normal breast tissues while downregulated in more aggressive breast cancer molecular subtypes (i. e. Luminal B, HER2 and triple negative), consistently with their function as repressors of the epithelial-to-mesenchymal transition (EMT). In particular miR-141-3p was found differentially expressed in breast cancer molecular subtypes in both H-CSS and TCGA-BRCA cohorts, and the combined analysis of all miR-200 family members demonstrated a slight predictive accuracy on H-CSS cancer specific survival at 12 years (survival c-statistic: 0. 646; 95%CI 0. 538-0. 754).
Nota:	Fundació Carreras
Nota:	This work was supported by Italian Ministry of Health (MoH) TRANSCAN Joint Transnational Call (JTC) 2013 co-funded by the European Regional Development Fund, "A way of making Europe" RRC-2014-2354565, Italian Ministry of Health (MoH) "Ricerca Corrente 2019" and "5×1000″ voluntary contributions" and partially supported by Associazione Italiana Ricerca sul Cancro (AIRC) Project Code: 16747.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biomarkers, Tumor ; Breast ; Breast Neoplasms ; Cell Line, Tumor ; Cohort Studies ; Disease-Free Survival ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs ; Middle Aged ; Multigene Family ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Predictive Value of Tests ; Risk Assessment ; Up-Regulation
Publicat a:	Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 2980, ISSN 2045-2322

DOI: 10.1038/s41598-021-82286-1
PMID: 33536459

14 p, 3.9 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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