Early T-Cell Precursor ALL and Beyond : Immature and Ambiguous Lineage T-ALL Subsets
Genescà, Eulàlia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Starza, Roberta la (Università degli Studi di Perugia)

Fecha:	2022
Resumen:	A wide range of immature acute leukemias (AL), ranging from acute myeloid leukemias with minimal differentiation to acute leukemias with an ambiguous lineage, i. e. , acute undifferentiated leukemias and mixed phenotype acute leukemia with T-or B-plus myeloid markers, cannot be definitely assigned to a single cell lineage. This somewhat "grey zone" of AL expresses partly overlapping features with the most immature forms of T-cell acute lymphoblastic leukemia (T-ALL), i. e. , early T-cell precursor ALL (ETP-ALL), near-ETP-ALL, and pro-T ALL. These are troublesome cases in terms of precise diagnosis because of their similarities and overlapping phenotypic features. Moreover, it has become evident that they share several genomic alterations, raising the question of how their phenotypes reflect distinct AL entities. The aim of this review was to provide a systematic overview of the genetic events associated with immature T-ALL and outline their relationship with treatment choices and outcomes, especially looking at the most recent preclinical and clinical studies. We wish to offer a basis for using the genetic information for new diagnostic algorithms, in order to better stratify patients and improve their management with more efficient and personalized therapeutic options. Understanding the genetic profile of this high-risk T-ALL subset is a prerequisite for changing the current clinical scenario.
Ayudas:	Instituto de Salud Carlos III PI19/01828 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-288
Nota:	Fundació Carreras
Nota:	Funding: This project was supported by the AECC (GC16173697BIGA) and ISCIII (PI19/01828), co-funded by ERDF/ESF, "A way to make Europe"/"Investing in your future", and CERCA/Generalitat de Catalunya SGR 2017 288 (GRC)/"La Caixa". R.L.S. is partially supported by the GILEAD Fellowship program 2021; by Comitato per la vita "Daniele Chianelli", Perugia, Italy; and by Associazione "Sergio Luciani", Fabriano, Italy.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Immature T-ALL ; ETP-ALL ; Diagnosis ; Genomics ; Outcome ; Treatment
Publicado en:	Cancers, Vol. 14 Núm. 8 (4-2 2022) , p. 1873, ISSN 2072-6694

DOI: 10.3390/cancers14081873
PMID: 35454781

17 p, 1.4 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Instituto de Investigación contra la Leucemia Josep Carreras
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