Effect of polyphenols intake on obesity-induced maternal programming
Fortunato, Isabela Monique (Post Graduate Program in Health Science. Universidade São Francisco (USF))
Dos Santos, Tanila Wood (Post Graduate Program in Health Science. Universidade São Francisco (USF))
Ferraz, Lucio Fábio Caldas (Post Graduate Program in Health Science. Universidade São Francisco (USF))
Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ribeiro, Marcelo Lima (Post Graduate Program in Health Science. Universidade São Francisco (USF))

Date:	2021
Abstract:	Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an imperative need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in vegetables and fruits that exert its anti-obesity effect through its pow-erful anti-oxidant and anti-inflammatory activities. Polyphenol supplementation has been proven to counteract the prejudicial effects of maternal obesity programming on progeny. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.
Grants:	Instituto de Salud Carlos III CD19/00228
Note:	Fundació Carreras
Note:	MLR acknowledges support from the Brazilian National Council for Scientific and Tech-nological Development (CNPq, 305402/2019-6). I.M.F. was supported by a scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES, Ministry of Education of Brazil). J.C.S. holds a Sara Borrell research contract from Instituto de Salud Carlos III (CD19/00228).
Note:	Funding: MLR acknowledges support from the Brazilian National Council for Scientific and Technological Development (CNPq, 305402/2019-6). I.M.F. was supported by a scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES, Ministry of Education of Brazil). J.C.S. holds a Sara Borrell research contract from Instituto de Salud Carlos III (CD19/00228).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bioactive compounds ; Nutraceutical ; Maternal obesity ; Adipose tissue ; Metabolic disorders
Published in:	Nutrients, Vol. 13 Núm. 7 (july 2021) , p. 2390, ISSN 2072-6643

DOI: 10.3390/nu13072390
PMID: 34371900

13 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles