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Pàgina inicial > Articles > Articles publicats > Underlying mechanisms involved in gambling disorder severity : |
Data: | 2023 |
Resum: | Gambling Disorder (GD) has a complex etiology that involves biological and environmental aspects. From a genetic perspective, neurotrophic factors (NTFs) polymorphisms have been associated with the risk of developing GD. The aim of this study was to assess the underlying mechanisms implicated in GD severity by considering the direct and mediational relationship between different variables including genetic, psychological, socio-demographic, and clinical factors. To do so, we used genetic variants that were significantly associated with an increased risk for GD and evaluated its relationship with GD severity through pathway analysis. We found that the interaction between these genetic variants and other different biopsychological features predicted a higher severity of GD. On the one hand, the presence of haplotype block 2, interrelated with haplotype block 3, was linked to a more dysfunctional personality profile and a worse psychopathological state, which, in turn, had a direct link with GD severity. On the other hand, having rs3763614 predicted higher general psychopathology and therefore, higher GD severity. The current study described the presence of complex interactions between biopsychosocial variables previously associated with the etiopathogenesis and severity of GD, while also supporting the involvement of genetic variants from the NTF family. |
Ajuts: | Ministerio de Ciencia e Innovación PDI2021-124887OB-I00 Instituto de Salud Carlos III PI20/00132 European Commission 728018 Instituto de Salud Carlos III CM21/00172 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Gambling disorder ; Severity ; Neurotrophic genes ; Socio-demographics ; Personality traits ; Psychopathology |
Publicat a: | Nutrients, Vol. 15 (january 2023) , ISSN 2072-6643 |
Obra relacionada: | Granero, Roser, ed.; Fernández-Aranda, Fernando, ed.; Jiménez-Murcia, Susana, ed. Eating disorders and addictive behaviors : implications for human health. Basel: MDPI, 2024. viii, 204 pàg. ISBN 978-3-7258-0575-4 https://doi.org/10.3390/books978-3-7258-0576-1 |
16 p, 987.5 KB |