Reparative cell therapy for the heart : critical internal appraisal of the field in response to recent controversies
Povsic, T.J. (Duke Clinical Research Institute. Duke University School of Medicine)
Sanz-Ruiz, R. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Climent, A.M. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Bolli, R. (Department of Medicine. School of Medicine. University of Louisville)
Taylor, D.A. (Center for Cell and Organ Biotechnology. Texas Heart Institute)
Gersh, B.J. (Department of Cardiovascular Medicine. Mayo Clinic College of Medicine)
Menasché, P. (Department of Cardiovascular Surgery. Georges Pompidou European Hospital)
Perin, E.C. (Center for Clinical Research. Texas Heart Institute)
Pompilio, G. (Vascular Biology and Regenerative Medicine Unit and Dept. of Cardiovascular Surgery. Centro Cardiologico Monzino IRCCS)
Atsma, D.E. (Faculteit der Sociale Wetenschappen. Instituut Psychologie. Gezondheids. Medische-Neuropsychologie)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
DeMaria, A.N. (Sulpizio Cardiovascular Center. UC San Diego Health)
Hare, J.M. (Interdisciplinary Stem Cell Institute and Division of Cardiology. Leonard M. Miller School of Medicine. University of Miami)
Henry, Timothy D (The Carl and Edyth Lindner Center for Research and Education. The Christ Hospital)
Janssens, S. (Centre for Molecular and Vascular Biology. Department of Cardiovascular Sciences. KU Leuven)
Kastrup, J. (Department of Cardiology. Centre for Cardiac. Vascular. Pulmonary and Infectious Diseases. Rigshospitalet)
Torella, D. (Molecular and Cellular Cardiology LAB. Department of Experimental and Clinical Medicine. Magna Graecia University)
Traverse, J.H. (Minneapolis Heart Institute Foundation. Abbott Northwestern Hospital)
Willerson, J.T. (Center for Clinical Research. Texas Heart Institute)
Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))

Date:	2021
Abstract:	The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Reparative cell therapy ; Myocardial repair and regeneration ; Stem cell therapy
Published in:	ESC Heart Failure, Vol. 8 Núm. 3 (june 2021) , p. 2306-2309, ISSN 2055-5822

DOI: 10.1002/ehf2.13256
PMID: 33652498

4 p, 85.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles