Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
García-Cosío, María Dolores (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
González-Vilchez, Francisco (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
López-Vilella, Raquel (Hospital Universitari i Politècnic La Fe (València))
Barge-Caballero, Eduardo (Complejo Hospitalario Universitario de A Coruña)
Gómez Bueno, Manuel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Martínez-Selles, Manuel (Hospital General Universitario Gregorio Marañón)
Arizón, J. M (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Rangel Sousa, Diego (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
González-Costello, José (Hospital Universitari de Bellvitge)
Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Pérez-Villa, Félix (Hospital Clínic i Provincial de Barcelona)
Molina, Beatriz Díaz. (Servicio de Cardiología. Hospital Universitario Central De Asturias)
Rábago, Gregorio (Servicio de Cirugía Cardiaca. Clínica Universidad De Navarra)
Portolés Ocampo, Ana (Hospital Universitario Miguel Servet (Saragossa))
de la Fuente Galán, Luis (Hospital Clínico Universitario de Valladolid)
Garrido Bravo, Iris (Servicio de Cardiología)
Delgado, Juan F. (Universidad Complutense de Madrid. Departamento de Medicina)

Data:	2021
Resum:	Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease. Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years. The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women. We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women. We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.
Nota:	Altres ajuts: Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV); Instituto de Salud Carlos III (ISCIII); Ministerio de Economía y Competitividad (MINECO).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Gender ; Female ; Heart transplantation ; Outcome ; Women ; Advanced heart failure ; Ventricular assist device
Publicat a:	Frontiers in Cardiovascular Medicine, Vol. 8 (february 2021) , p. 630113, ISSN 2297-055X

DOI: 10.3389/fcvm.2021.630113
PMID: 33718453

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