Efficient controlled release of cannabinoids loaded in γ‑CD‑MOFs and DPPC liposomes as novel delivery systems in oral health
Rodriguez Martinez, Jorge (Universitat Autònoma de Barcelona. Departament de Química)
Sánchez-Martín, María-Jesús ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Química)
Valiente Malmagro, Manuel ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Química)
Data: |
2023 |
Resum: |
Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the frst time in case of MOFs loaded with cannabinoids. In vitro experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can fow to the pulp tissues and exert its analgesic efect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by diferent techniques, and is was demonstrated that DDS is an efcient way to carry the drug through dental tissues without compromising theirstructure. |
Ajuts: |
Agència de Gestió d'Ajuts Universitaris i de Recerca FI-2018
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Nota: |
Altres ajuts: acords transformatius de la UAB |
Nota: |
Altres ajuts: This work has been funded by ALBA Synchrotron through granted proposal (grant reference: 2020024303) |
Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
γ-Cyclodextrin-MOFs (γ-CD-MOFs) ;
Cannabidiol (CBD) ;
DPPC liposomes (1,2-dipalmitoyl-sn-glycero-3- phosphocholine) ;
Oral health ;
Synchrotron FTIR microspectroscopy |
Publicat a: |
Mikrochimica acta, Vol. 190 (March 2023) , art. 125, ISSN 1436-5073 |
DOI: 10.1007/s00604-023-05692-4
PMID: 36894805
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Registre creat el 2023-03-14, darrera modificació el 2023-05-18