Efficient controlled release of cannabinoids loaded in γ‑CD‑MOFs and DPPC liposomes as novel delivery systems in oral health
Rodriguez Martinez, Jorge (Universitat Autònoma de Barcelona. Departament de Química)
Sánchez-Martín, María-Jesús (Universitat Autònoma de Barcelona. Departament de Química)
Valiente Malmagro, Manuel (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2023
Abstract:	Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the frst time in case of MOFs loaded with cannabinoids. In vitro experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can fow to the pulp tissues and exert its analgesic efect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by diferent techniques, and is was demonstrated that DDS is an efcient way to carry the drug through dental tissues without compromising theirstructure.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca FI-2018
Note:	Altres ajuts: acords transformatius de la UAB
Note:	Altres ajuts: This work has been funded by ALBA Synchrotron through granted proposal (grant reference: 2020024303)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	γ-Cyclodextrin-MOFs (γ-CD-MOFs) ; Cannabidiol (CBD) ; DPPC liposomes (1,2-dipalmitoyl-sn-glycero-3- phosphocholine) ; Oral health ; Synchrotron FTIR microspectroscopy
Published in:	Mikrochimica acta, Vol. 190 (March 2023) , art. 125, ISSN 1436-5073

DOI: 10.1007/s00604-023-05692-4
PMID: 36894805

10 p, 1.9 MB

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