Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia
Escolà-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau)
Julve i Gil, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Blanco Vaca, Francisco (Institut d'Investigació Biomèdica Sant Pau)

Fecha:	2021
Resumen:	Purpose of Review: We seek to establish whether high-density lipoprotein HDL metabolism and reverse cholesterol transport (RCT) impairment is an intrinsic feature of familial hypercholesterolemia (FH). Recent Findings: RCT from macrophages (m-RCT), a vascular cell type of major influence on atherosclerosis, is impaired in FH due to defective low-density lipoprotein receptor (LDLR) function via both the HDL- and LDL-mediated pathways. Potential mechanisms include impaired HDL metabolism, which is linked to increased LDL levels, as well as the increased transport of cellular unesterified cholesterol to LDL, which presents a defective catabolism. Summary: RCT dysfunction is consistently associated with mutation-positive FH linked to decreased HDL levels as well as impaired HDL remodeling and LDLR function. It remains to be explored whether these alterations are also present in less well-characterized forms of FH, such as cases with no identified mutations, and whether they are fully corrected by current standard treatments.
Ayudas:	Instituto de Salud Carlos III /CPII18/00004 Ministerio de Ciencia, Innovación y Universidades RyC-20172879 Instituto de Salud Carlos III PI17/00232 Instituto de Salud Carlos III PI18/00164 Instituto de Salud Carlos III PI19/00136
Nota:	Altres ajuts: Fundació la Marató de TV3 12/C/2015, 201602.31; Red de Investigación "Enfermedades Metabólicas y Cáncer" RED2018-102799-T
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió de l'autor
Materia:	HDL ; LDL receptor ; Macrophage ; Autosomal dominant hypercholesterolemia
Publicado en:	Current Atherosclerosis Reports, Vol. 23 Núm. 6 (june 2021) , p. 29, ISSN 1534-6242

DOI: 10.1007/s11883-021-00928-1
PMID: 33914189

23 p, 326.7 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados