Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia
Tagliabue, Susanna (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina (Barcelona))
da Prat, Ivette Chochron (Hospital Universitari Vall d'Hebron)
Sanchez-Guerrero, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Serra, Isabel (Barcelona Supercomputing Center)
Kacprzak, Michał (Nalecz Institute of Biocybernetics and Biomedical Engineering PAS (Polònia))
Maruccia, Federica (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Silva Martinez, Olga (Hospital Universitari Vall d'Hebron)
Weigel, Udo M. (Mediterranean Technology Park (Barcelona))
Nadal Clanchet, Miriam de (Universitat Autònoma de Barcelona)
Poca Pastor, María Antonia (Hospital Universitari Vall d'Hebron)
Durduran, Turgut (Institució Catalana de Recerca i Estudis Avançats)
Lindner, Claus (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina)

Data:	2023
Resum:	The optical measurement of cerebral oxygen metabolism was evaluated. Compare optically derived cerebral signals to the electroencephalographic bispectral index (BIS) sensors to monitor propofol-induced anesthesia during surgery. Relative cerebral metabolic rate of oxygen () and blood flow (rCBF) were measured by time-resolved and diffuse correlation spectroscopies. Changes were tested against the relative BIS (rBIS) ones. The synchronism in the changes was also assessed by the R-Pearson correlation. In 23 measurements, optically derived signals showed significant changes in agreement with rBIS: during propofol induction, rBIS decreased by 67% [interquartile ranges (IQR) 62% to 71%], by 33% (IQR 18% to 46%), and rCBF by 28% (IQR 10% to 37%). During recovery, a significant increase was observed for rBIS (48%, IQR 38% to 55%), (29%, IQR 17% to 39%), and rCBF (30%, IQR 10% to 44%). The significance and direction of the changes subject-by-subject were tested: the coupling between the rBIS, , and rCBF was witnessed in the majority of the cases (14/18 and 12/18 for rCBF and 19/21 and 13/18 for in the initial and final part, respectively). These changes were also correlated in time (to , ). Optics can reliably monitor in such conditions.
Ajuts:	European Commission. Horizon 2020 675332 European Commission. Horizon 2020 101016087 European Commission. Horizon 2020 101017113 European Commission. Horizon 2020 871124 Ministerio de Economía y Competitividad SEV-2015-0522 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1380 Fundació la Marató de TV3 201724.31 Fundació la Marató de TV3 201709.31
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Diffuse correlation spectroscopy ; Time-resolved spectroscopy ; Propofol-induced anesthesia ; Bispectral index ; Diffuse optics ; Cerebral blood flow ; Cerebral metabolic rate of oxygen ; Cerebral physiological changes ; Near-infrared spectroscopy
Publicat a:	Neurophotonics, Vol. 10 (march 2023) , ISSN 2329-4248

DOI: 10.1117/1.NPh.10.1.015006
PMID: 36911206

23 p, 3.0 MB

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