Co-evolution of large inverted repeats and G-quadruplex DNA in fungal mitochondria may facilitate mitogenome stability : the case of Malassezia
Christinaki, Anastasia C. (Westerdijk Fungal Biodiversity Institute)
Theelen, Bart (Westerdijk Fungal Biodiversity Institute)
Zania, Alkmini (Westerdijk Fungal Biodiversity Institute)
Coutinho, Selene Dall' Acqua (Paulista University. Laboratory of Molecular and Cellular Biology)
Cabañes Sáenz, Francisco Javier (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Boekhout, Teun (King Saud University. College of Science)
Kouvelis, Vassili N. (National and Kapodistrian University of Athens. Department of Biology)

Date:	2023
Abstract:	Mitogenomes are essential due to their contribution to cell respiration. Recently they have also been implicated in fungal pathogenicity mechanisms. Members of the basidiomycetous yeast genus Malassezia are an important fungal component of the human skin microbiome, linked to various skin diseases, bloodstream infections, and they are increasingly implicated in gut diseases and certain cancers. In this study, the comparative analysis of Malassezia mitogenomes contributed to phylogenetic tree construction for all species. The mitogenomes presented significant size and gene order diversity which correlates to their phylogeny. Most importantly, they showed the inclusion of large inverted repeats (LIRs) and G-quadruplex (G4) DNA elements, rendering Malassezia mitogenomes a valuable test case for elucidating the evolutionary mechanisms responsible for this genome diversity. Both LIRs and G4s coexist and convergently evolved to provide genome stability through recombination. This mechanism is common in chloroplasts but, hitherto, rarely found in mitogenomes.
Note:	Federation of European Microbiological Societies (FEMS) research and training grant-FEMS-GO-2020-199'
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Coevolution ; Phylogenetics ; Mitochondrial genome ; Genomics ; Comparative genomics ; Genome evolution ; Evolution ; Microbiology ; Fungal genomics
Published in:	Scientific reports, Vol. 13 (april 2023) , ISSN 2045-2322

DOI: 10.1038/s41598-023-33486-4
PMID: 37072481

11 p, 2.4 MB

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