Functional changes in prefrontal cortex following frequency-specific training
Bach-Morrow, L. (Think Interfaces)
Boccalatte, F. (Department of Pathology. NYU Langone Medical Center)
DeRosa, A. (Department of Mathematics. University of Maryland)
Devos, D. (Department of Neurology. University Hospital. Univ of Lille)
García-Sánchez, Carmen (Institut d'Investigació Biomèdica Sant Pau)
Inglese, M. (Neurology Department. Icahn School of Medicine at Mount Sinai)
Droby, A. (Neurology Department. Icahn School of Medicine at Mount Sinai)

Date:	2022
Abstract:	Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the neural mechanisms underlying the utility of non-invasive frequency-specific training systems in ADHD remediation remain underexplored. To address this issue, we created a portable electroencephalography (EEG)-based wireless system consisting of a novel headset, electrodes, and neuro program, named frequency specific cognitive training (FSCT). In a double-blind, randomized, controlled study we investigated the training effects in N = 46 school-age children ages 6-18 years with ADHD. 23 children in experimental group who underwent FCST training showed an increase in scholastic performance and meliorated their performance on neuropsychological tests associated with executive functions and memory. Their results were compared to 23 age-matched participants who underwent training with placebo (pFSCT). Electroencephalogram (EEG) data collected from participants trained with FSCT showed a significant increase in 14-18 Hz EEG frequencies in PFC brain regions, activities that indicated brain activation in frontal brain regions, the caudate nucleus, and putamen. These results demonstrate that FSCT targets specific prefrontal and striatal areas in children with ADHD, suggesting a beneficial modality for non-invasive modulation of brain areas implicated in attention and executive functions.
Grants:	European Commission 633190
Note:	Altres ajuts: European ANR (COEN4007-18, COEN-0003-01); PHRC grants from the French Ministry of Health and research funding; France Parkinson and ARSLA charity.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adolescent ; Attention Deficit Disorder with Hyperactivity ; Brain ; Brain Mapping ; Child ; Humans ; Magnetic Resonance Imaging ; Prefrontal Cortex
Published in:	Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 20316, ISSN 2045-2322

DOI: 10.1038/s41598-022-24088-7
PMID: 36434008

10 p, 2.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles