Remote ischaemic conditioning : defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop
Bell, R.M. (The Hatter Cardiovascular Institute. University College London)
Basalay, M. (The Hatter Cardiovascular Institute. University College London)
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca))
Beikoghli Kalkhoran, S. (The Hatter Cardiovascular Institute. University College London)
Carr, R.D. (The Hatter Cardiovascular Institute. University College London)
Cunningham, J. (Royal Free Hospital)
Davidson, Sean M (The Hatter Cardiovascular Institute. University College London)
England, T.J. (Stroke. Division of Mental Health and Clinical Neurosciences. School of Medicine. University of Nottingham)
Giesz, S. (The Hatter Cardiovascular Institute. University College London)
Ghosh, A.K. (The Hatter Cardiovascular Institute. University College London)
Golforoush, P. (The Hatter Cardiovascular Institute. University College London)
Gourine, A.V. (Centre for Cardiovascular and Metabolic Neuroscience. Neuroscience. Physiology and Pharmacology. University College London)
Hausenloy, D. J. (Cardiovascular Research Center. College of Medical and Health Sciences. Asia University)
Heusch, G. (Institute for Pathophysiology. West German Heart and Vascular Center. University of Duisburg-Essen)
Ibanez, B. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Kleinbongard, P. (Institute for Pathophysiology. West German Heart and Vascular Center. University of Duisburg-Essen)
Lecour, Sandrine (University of Cape Town)
Lukhna, K. (University of Cape Town)
Ntsekhe, M. (University of Cape Town)
Ovize, M. (INSERM U1060. CarMeN Laboratory. Université de Lyon. Groupement Hospitalier Est)
Salama, A.D. (Royal Free Hospital)
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Walker, J.M. (The Hatter Cardiovascular Institute. University College London)
Yellon, D.M. (The Hatter Cardiovascular Institute. University College London)

Date:	2022
Abstract:	The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2-ERIC-PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely due to the disconnect between preclinical and clinical studies. Discussion points included how to adapt preclinical animal studies to mirror the patient presenting with an acute myocardial infarction, as well as how to refine patient selection in clinical studies to account for co-morbidities and ongoing therapy. These latter scenarios can modify cytoprotective signalling and need to be taken into account to allow for a more robust outcome when powered appropriately. The workshop also discussed the potential for RIC in other disease settings including ischaemic stroke, cardio-oncology and COVID-19. The workshop, therefore, put forward specific classifications which could help identify so-called responders vs. non-responders in both the preclinical and clinical settings.
Grants:	Agencia Estatal de Investigación PGC2018-094025-B-I00
Note:	Altres ajuts: German Research Foundation (CRC 1116 B8); British Heart Foundation (PG/19/51/34493, PG/21/10798); Rosetrees Foundation (Seedcorn2021\100092); Fondo Europeo de Desarrollo Regional (FFEDER); Duke-NUS Signature Research Programme funded by the Ministry of Health, Singapore Ministry of Health's National Medical Research Council under its Singapore Translational Research Investigator Award (MOH-STaR21jun-0003); Centre, Grant scheme (NMRC CG21APR1006); Collaborative Centre Grant scheme (NMRC/CG21APRC006).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ischaemia reperfusion injury ; Remote ischaemic conditioning ; Cardiovascular
Published in:	Basic Research in Cardiology, Vol. 117 Núm. 1 (december 2022) , p. 39, ISSN 1435-1803

DOI: 10.1007/s00395-022-00947-2
PMID: 35970954

12 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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