Predictors and changes of physical activity in idiopathic pulmonary fibrosis
Badenes-Bonet, Diana (Institut Hospital del Mar d'Investigacions Mèdiques)
Rodó-Pin, Anna (Institut Hospital del Mar d'Investigacions Mèdiques)
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)
Vicens-Zygmunt, Vanesa (Institut d'Investigació Biomèdica de Bellvitge)
Bermudo, Guadalupe (Institut d'Investigació Biomèdica de Bellvitge)
Hernández-González, Fernanda (Hospital Clínic i Provincial de Barcelona)
Portillo, Karina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez-Llorens, Juana (Institut Hospital del Mar d'Investigacions Mèdiques)
Chalela, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques)
Caguana, Oswaldo (Institut Hospital del Mar d'Investigacions Mèdiques)
Sellarés, Jacobo (Hospital Clínic i Provincial de Barcelona)
Molina-Molina, Maria (Institut d'Investigació Biomèdica de Bellvitge)
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Gea, Joaquim (Institut Hospital del Mar d'Investigacions Mèdiques)
Rodríguez-Chiaradia, Diego Agustín (Institut Hospital del Mar d'Investigacions Mèdiques)
Balcells, Eva (Institut Hospital del Mar d'Investigacions Mèdiques)

Date:	2022
Abstract:	Background: Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of changes in PA in the course of the disease. The aim of the present study was to investigate the relationship between baseline PA and a wide range of variables in IPF, to assess its longitudinal changes at 12 months and its impact on progression free-survival. Methods: PA was assessed by accelerometer and physiological, clinical, psychological factors and health-related quality of life were evaluated in subjects with IPF at baseline and at 12 month follow-up. Predictors of PA were determined at baseline, evolution of PA parameters was described and the prognostic role of PA evolution was also established. Results: Forty participants with IPF were included and 22 completed the follow-up. At baseline, subjects performed 5765 (3442) daily steps and spent 64 (44) minutes/day in moderate to vigorous PA. Multivariate regression models showed that at baseline, a lower six-minute walked distance, lower quadriceps strength (QMVC), and a higher depression score in the Hospital Anxiety and Depression scale were associated to lower daily step number. In addition, being in (Gender-Age-Physiology) GAP III stage, having a BMI ≥ 25 kg/m and lower QMVC or maximum inspiratory pressure were factors associated with sedentary behaviour. Adjusted for age, gender and forced vital capacity (FVC) (%pred. ) a lower progression-free survival was evidenced in those subjects that decreased PA compared to those that maintained, or even increased it, at 12 months [HR 12. 1 (95% CI, 1. 9-78. 8); p = 0. 009]. Conclusion: Among a wide range of variables, muscle strength and depression symptoms have a predominant role in PA in IPF patients. Daily PA behaviour and its evolution should be considered in IPF clinical assessment and as a potential complementary indicator of disease prognosis.
Note:	Altres ajuts: SEPAR 2017 (Fellowship); Rio Hortega, ISCIII (Project and fellowship).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Physical activity ; Idiopathic pulmonary fibrosis ; Predictors ; Muscle strength ; Depression ; Prognosis
Published in:	BMC Pulmonary Medicine, Vol. 22 Núm. 1 (december 2022) , p. 340, ISSN 1471-2466

DOI: 10.1186/s12890-022-02134-4
PMID: 36085057

9 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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