Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing
Sarreshtehdari, Amirhossein (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Burdío, Fernando (Institut Hospital del Mar d'Investigacions Mèdiques)
López-Alonso, Borja (Universidad de Zaragoza. Department of Electronic Engineering and Communications)
Lucía, Óscar (Universidad de Zaragoza. Department of Electronic Engineering and Communications)
Burdio, José Miguel (Universidad de Zaragoza. Department of Electronic Engineering and Communications)
Villamonte, María (Institut Hospital del Mar d'Investigacions Mèdiques)
Andaluz Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
García Arnas, Félix (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Berjano, Enrique (Universitat Politècnica de València. Departament d'Enginyeria Electrònica)
Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Fundació Hospital Clínic Veterinari)

Data:	2023
Resum:	Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1 mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0. 008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2. 1, at 0. 008 mL/g for 16 min. Group 2. 2 at 0. 03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4. 31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE's effects on healthy tissue.
Ajuts:	Instituto de Salud Carlos III PI17/0048 Instituto de Salud Carlos III PI21/00440 Ministerio de Economía y Competitividad RTI2018-094357-B-C22 Ministerio de Economía y Competitividad RTI2018-094357-B-C21
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cancer ; Diseases ; Health care ; Medical research
Publicat a:	Scientific reports, Vol. 13 (may 2023) , ISSN 2045-2322

DOI: 10.1038/s41598-023-33487-3
PMID: 37130847

9 p, 1.4 MB

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