Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1 -Mutant Myelodysplastic Syndromes With Ringed Sideroblasts
Ademà, Vera (The University of Texas MD Anderson Cancer Center)
Ma, Feiyang (University of Michigan)
Kanagal-Shamanna, Rashmi (The University of Texas MD Anderson Cancer Center)
Thongon, Natthakan (The University of Texas MD Anderson Cancer Center)
Montalban-Bravo, Guillermo (The University of Texas)
Yang, Hui (The University of Texas)
Peslak, Scott A. (Children's Hospital of Philadelphia (Pennsilvània))
Wang, Feng (The University of Texas MD Anderson Cancer Center)
Acha, Pamela (Universitat Autònoma de Barcelona)
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Lockyer, Pamela (The University of Texas MD Anderson Cancer Center)
Cassari, Margherita (University of Florence)
Maciejewski, Jaroslaw P. (Cleveland Clinic Foundation)
Visconte, Valeria (Cleveland Clinic Foundation)
Gañán-Gómez, Irene (The University of Texas MD Anderson Cancer Center)
Song, Yuanbin (Sun Yat-sen University Cancer Center)
Bueso-Ramos, Carlos (The University of Texas MD Anderson Cancer Center)
Pellegrini, Matteo (University of California)
Tan, Tuyet M. (Univerity of California San Diego)
Bejar, Rafael (Univerity of California San Diego)
Carew, Jennifer S. (University of Arizona Cancer Center)
Halene, Stephanie (Yale University School of Medicine)
Santini, Valeria (University of Florence)
Al-Atrash, Gheath (The University of Texas MD Anderson Cancer Center)
Clise-Dwyer, Karen (The University of Texas MD Anderson Cancer Center)
Garcia-Manero, Guillermo (The University of Texas MD Anderson Cancer Center)
Blobel, Gerd A. (Children's Hospital of Philadelphia (Pennsilvània))
Colla, Simona (The University of Texas MD Anderson Cancer Center)

Date:	2022
Abstract:	SF3B1 -mutant MDS-RS is associated with buildup of erythroid progenitor cells upregulating EIF2AK1-associated heme deficiency response and autophagy genes. Targeting EIF2AK1 relieves the dysregulated progenitor phenotype. MDS-RS are characterized by significant anemia. Patients with MDS-RS die from a shortage of red blood cells and the side effects of iron overload due to their constant need for transfusions. Our study has implications for the development of therapies to achieve long-lasting hematologic responses.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Blood Cancer Discovery, Vol. 3 (august 2022) , p. 554-567, ISSN 2643-3249

DOI: 10.1158/2643-3230.BCD-21-0220
PMID: 35926182

14 p, 9.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles